Bicyclo[2.2.1]heptane, 2-(5-bromo-2-methoxyphenoxy)-, (1R-exo)-

Base Information

Chemical Name:Bicyclo[2.2.1]heptane, 2-(5-bromo-2-methoxyphenoxy)-, (1R-exo)-
CAS No.:172721-28-7
Molecular Formula:C₁₄H₁₇BrO₂
Molecular Weight:297.192
Hs Code.:
DSSTox Substance ID:DTXSID801173268

Synonyms:DTXSID801173268;Bicyclo[2.2.1]heptane, 2-(5-bromo-2-methoxyphenoxy)-, (1R-exo)-;172721-28-7

Suppliers and Price of Bicyclo[2.2.1]heptane, 2-(5-bromo-2-methoxyphenoxy)-, (1R-exo)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Bicyclo[2.2.1]heptane, 2-(5-bromo-2-methoxyphenoxy)-, (1R-exo)-

Chemical Property:

XLogP3:4.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:296.04119
Heavy Atom Count:17
Complexity:271

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=C(C=C(C=C1)Br)OC2CC3CCC2C3
Isomeric SMILES:COC1=C(C=C(C=C1)Br)O[C@@H]2C[C@H]3CC[C@@H]2C3

Technology Process of Bicyclo[2.2.1]heptane, 2-(5-bromo-2-methoxyphenoxy)-, (1R-exo)-

There total 1 articles about Bicyclo[2.2.1]heptane, 2-(5-bromo-2-methoxyphenoxy)-, (1R-exo)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 497-36-9,36779-79-0
endo-norborneol

: 37942-01-1
5-bromo-2-methoxyphenol

: 172721-28-7
(R)-exo-2-(5-bromo-2-methoxyphenoxy)bicyclo<2.2.1>heptane

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 25 ℃; for 18h;
DOI:10.1021/jm9505066

Reference yield:

: 172721-28-7
(R)-exo-2-(5-bromo-2-methoxyphenoxy)bicyclo<2.2.1>heptane

: (R)-(-)-exo-4-<3-(bicyclo<2.2.1>hept-2-yloxy)-4-methoxyphenyl>benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) n-BuLi, 2.) 1 M ZnCl₂, 3.) Pd(PPh₃)4

2: 1 N NaOH / ethanol / 1.5 h / Heating

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; zinc(II) chloride; In ethanol;
DOI:10.1021/jm9505066

Reference yield:

: 619-42-1
4-methoxycarbonylphenyl bromide

: 172721-28-7
(R)-exo-2-(5-bromo-2-methoxyphenoxy)bicyclo<2.2.1>heptane

: 3'-((1R,2R,4S)-Bicyclo[2.2.1]hept-2-yloxy)-4'-methoxy-biphenyl-4-carboxylic acid methyl ester

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; zinc(II) chloride; Multistep reaction;
DOI:10.1021/jm9505066