(E)-6-(3-(3-oxo-3-phenylpropyl)-1H-indol-2-yl)-1-phenylhex-2-en-1-one

Base Information

• Chemical Name: (E)-6-(3-(3-oxo-3-phenylpropyl)-1H-indol-2-yl)-1-phenylhex-2-en-1-one
• CAS No.: 1260083-31-5
• Molecular Formula: C₂₉H₂₇NO₂
• Molecular Weight: 421.539
• Mol file: 1260083-31-5.mol

Synonyms:(E)-6-(3-(3-oxo-3-phenylpropyl)-1H-indol-2-yl)-1-phenylhex-2-en-1-one

Chemical Property of (E)-6-(3-(3-oxo-3-phenylpropyl)-1H-indol-2-yl)-1-phenylhex-2-en-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-6-(3-(3-oxo-3-phenylpropyl)-1H-indol-2-yl)-1-phenylhex-2-en-1-one

There total 1 articles about (E)-6-(3-(3-oxo-3-phenylpropyl)-1H-indol-2-yl)-1-phenylhex-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

3-(2-(pent-4-enyl)-1H-indol-3-yl)-1-phenylpropan-1-one (1260083-40-6) + Phenyl vinyl ketone (768-03-6,26742-84-7) → (E)-6-(3-(3-oxo-3-phenylpropyl)-1H-indol-2-yl)-1-phenylhex-2-en-1-one (1260083-31-5)

Guidance literature:

With 1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene[2-(iso-propoxy)-5-(N,N-dimethylaminosulfonyl)phenyl]methylene ruthenium(II) dichloride; In dichloromethane; optical yield given as %de; diastereoselective reaction; Reflux; Inert atmosphere;

DOI:10.1002/anie.201003919

Reference yield: 83.0%

(E)-6-(3-(3-oxo-3-phenylpropyl)-1H-indol-2-yl)-1-phenylhex-2-en-1-one (1260083-31-5) → 3-(6-(2-oxo-2-phenylethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)-1-phenylpropan-1-one (1260083-13-3)

Guidance literature:

With (S)-3,3'-bis(triphenylsilyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; In toluene; at 0 ℃; for 4h; optical yield given as %ee; enantioselective reaction; Inert atmosphere; Molecular sieve;

DOI:10.1002/anie.201003919

upstream raw materials:

3-(2-(pent-4-enyl)-1H-indol-3-yl)-1-phenylpropan-1-one

Phenyl vinyl ketone

Downstream raw materials:

3-(6-(2-oxo-2-phenylethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)-1-phenylpropan-1-one