N'-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-N'-[2-fluoro-3-(3-methoxy-8-methoxymethoxy-quinoxalin-2-yl)-benzoyl]-hydrazinecarboxylic acid allyl ester

Base Information

Chemical Name:N'-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-N'-[2-fluoro-3-(3-methoxy-8-methoxymethoxy-quinoxalin-2-yl)-benzoyl]-hydrazinecarboxylic acid allyl ester
CAS No.:913375-45-8
Molecular Formula:C₃₀H₃₉FN₄O₇Si
Molecular Weight:614.746
Hs Code.:

<i>N</i>'-[2-(<i>tert</i>-butyl-dimethyl-silanyloxy)-ethyl]-<i>N</i>'-[2-fluoro-3-(3-methoxy-8-methoxymethoxy-quinoxalin-2-yl)-benzoyl]-hydrazinecarboxylic acid allyl ester

Synonyms:N'-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-N'-[2-fluoro-3-(3-methoxy-8-methoxymethoxy-quinoxalin-2-yl)-benzoyl]-hydrazinecarboxylic acid allyl ester

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Chemical Property of N'-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-N'-[2-fluoro-3-(3-methoxy-8-methoxymethoxy-quinoxalin-2-yl)-benzoyl]-hydrazinecarboxylic acid allyl ester

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Technology Process of N'-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-N'-[2-fluoro-3-(3-methoxy-8-methoxymethoxy-quinoxalin-2-yl)-benzoyl]-hydrazinecarboxylic acid allyl ester

There total 9 articles about N'-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-N'-[2-fluoro-3-(3-methoxy-8-methoxymethoxy-quinoxalin-2-yl)-benzoyl]-hydrazinecarboxylic acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 688809-87-2
allyl 2-[2-(tertbutyldimethylsilyloxy)ethyl]hydrazinecarboxylate

: 913375-44-7
2-fluoro-3-(3-methoxy-8-methoxymethoxy-quinoxalin-2-yl)-benzoic acid

: 913375-45-8
N'-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-N'-[2-fluoro-3-(3-methoxy-8-methoxymethoxy-quinoxalin-2-yl)-benzoyl]-hydrazinecarboxylic acid allyl ester

Guidance literature:: With 3,3-dimethyl-D-cysteine; triethylamine; In chloroform;
DOI:10.1016/j.bmcl.2006.07.026

Reference yield:

: 913375-41-4
3-ethoxyoxalyl-2-fluoro-benzoic acid methyl ester

: 913375-45-8
N'-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-N'-[2-fluoro-3-(3-methoxy-8-methoxymethoxy-quinoxalin-2-yl)-benzoyl]-hydrazinecarboxylic acid allyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 48 percent / AcOH / toluene

2: SOCl₂ / dimethylformamide

3: TBAF / tetrahydrofuran

4: NaH

5: aq. NaOH / methanol; tetrahydrofuran

6: 69 percent / DMC; Et₃N / CHCl₃

With sodium hydroxide; thionyl chloride; 3,3-dimethyl-D-cysteine; tetrabutyl ammonium fluoride; sodium hydride; acetic acid; triethylamine; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2006.07.026

Reference yield:

: 913375-43-6
3-(3-chloro-8-methoxymethoxy-quinoxalin-2-yl)-2-fluoro-benzoic acid methyl ester

: 913375-45-8
N'-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-N'-[2-fluoro-3-(3-methoxy-8-methoxymethoxy-quinoxalin-2-yl)-benzoyl]-hydrazinecarboxylic acid allyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: NaH

2: aq. NaOH / methanol; tetrahydrofuran

3: 69 percent / DMC; Et₃N / CHCl₃

With sodium hydroxide; 3,3-dimethyl-D-cysteine; sodium hydride; triethylamine; In tetrahydrofuran; methanol; chloroform;
DOI:10.1016/j.bmcl.2006.07.026