Technology Process of (3aR,4S,6R,7S,7aR)-2-Benzoyl-3-benzyl-7-(tert-butyl-dimethyl-silanyloxymethyl)-6-hydroxy-4-methyl-5-methylene-octahydro-isoindol-1-one
There total 15 articles about (3aR,4S,6R,7S,7aR)-2-Benzoyl-3-benzyl-7-(tert-butyl-dimethyl-silanyloxymethyl)-6-hydroxy-4-methyl-5-methylene-octahydro-isoindol-1-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
at 0 - 20 ℃;
for 0.5h;
DOI:10.1021/jo00347a034
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 100 percent / K2CO3 / diethyl ether; H2O / ice bath
2: sodium ethanolate / ethanol; diethyl ether / 15 h / Ambient temperature
3: 90 percent / acetonitrile; H2O / 2 h / 70 °C
4: 75 percent / sodium cyanoborohydride, chloroacetic acid / methanol / 1 h / Ambient temperature
5: n-BuLi / tetrahydrofuran; hexane / -78 - 25 °C
6: triethylamine / tetrahydrofuran; hexane
7: 62 percent / 2,6-di-tert-butylhydroquinone / toluene / 78 h / 150 °C
8: 0.05 g / MCPBA / CH2Cl2 / 0.5 h / 0 - 20 °C
With
n-butyllithium; 2,6-di-tert-butyl-4-hydroxyphenol; sodium ethanolate; sodium cyanoborohydride; potassium carbonate; triethylamine; chloroacetic acid; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; dichloromethane; water; toluene; acetonitrile;
DOI:10.1021/jo00347a034
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 90 percent / acetonitrile; H2O / 2 h / 70 °C
2: 75 percent / sodium cyanoborohydride, chloroacetic acid / methanol / 1 h / Ambient temperature
3: n-BuLi / tetrahydrofuran; hexane / -78 - 25 °C
4: triethylamine / tetrahydrofuran; hexane
5: 62 percent / 2,6-di-tert-butylhydroquinone / toluene / 78 h / 150 °C
6: 0.05 g / MCPBA / CH2Cl2 / 0.5 h / 0 - 20 °C
With
n-butyllithium; 2,6-di-tert-butyl-4-hydroxyphenol; sodium cyanoborohydride; triethylamine; chloroacetic acid; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; methanol; hexane; dichloromethane; water; toluene; acetonitrile;
DOI:10.1021/jo00347a034
