methyl (S)-2-((tert-butoxycarbonyl)amino)-5-(4-((2-fluorobenzyl)oxy)phenyl)-5-oxopentanoate

Base Information

Chemical Name:methyl (S)-2-((tert-butoxycarbonyl)amino)-5-(4-((2-fluorobenzyl)oxy)phenyl)-5-oxopentanoate
CAS No.:934240-60-5
Molecular Formula:C₂₄H₂₈FNO₆
Molecular Weight:445.488
Hs Code.:

Synonyms:methyl (S)-2-((tert-butoxycarbonyl)amino)-5-(4-((2-fluorobenzyl)oxy)phenyl)-5-oxopentanoate

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Chemical Property of methyl (S)-2-((tert-butoxycarbonyl)amino)-5-(4-((2-fluorobenzyl)oxy)phenyl)-5-oxopentanoate

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Technology Process of methyl (S)-2-((tert-butoxycarbonyl)amino)-5-(4-((2-fluorobenzyl)oxy)phenyl)-5-oxopentanoate

There total 8 articles about methyl (S)-2-((tert-butoxycarbonyl)amino)-5-(4-((2-fluorobenzyl)oxy)phenyl)-5-oxopentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1072951-78-0
(4-((2-fluorobenzyl)oxy)phenyl)boronic acid

: 1-methyl 5-(pyridin-2-yl) (tert-butoxycarbonyl)-L-glutamate

: 934240-60-5
methyl (S)-2-((tert-butoxycarbonyl)amino)-5-(4-((2-fluorobenzyl)oxy)phenyl)-5-oxopentanoate

Guidance literature:: With palladium diacetate; triphenylphosphine; In 1,4-dioxane; at 50 ℃; for 16h;

Reference yield: 53.0%

: 934240-59-2
1-[(4-bromophenoxy)methyl]-2-fluorobenzene

: 108963-96-8
(S)-1-tert-butoxycarbonyl-5-methoxycarbonyl-pyrrolidin-2-one

: 934240-60-5
methyl (S)-2-((tert-butoxycarbonyl)amino)-5-(4-((2-fluorobenzyl)oxy)phenyl)-5-oxopentanoate

Guidance literature:: 1-[(4-bromophenoxy)methyl]-2-fluorobenzene; With iodine; magnesium; ethylene dibromide; In tetrahydrofuran; for 5h; Inert atmosphere; Reflux; Large scale;

(S)-1-tert-butoxycarbonyl-5-methoxycarbonyl-pyrrolidin-2-one; In tetrahydrofuran; at -60 - -50 ℃; for 7h; chemoselective reaction; Inert atmosphere; Large scale;
DOI:10.1021/acs.oprd.0c00382

Reference yield:

: 108963-96-8
(S)-1-tert-butoxycarbonyl-5-methoxycarbonyl-pyrrolidin-2-one

: 934240-60-5
methyl (S)-2-((tert-butoxycarbonyl)amino)-5-(4-((2-fluorobenzyl)oxy)phenyl)-5-oxopentanoate

Guidance literature:: 1-[(4-bromophenoxy)methyl]-2-fluorobenzene; With iodine; magnesium; ethylene dibromide; In tetrahydrofuran; at 70 - 75 ℃; for 4h;

(S)-1-tert-butoxycarbonyl-5-methoxycarbonyl-pyrrolidin-2-one; In tetrahydrofuran; at -60 ℃; for 4h; Product distribution / selectivity;