[10R]-10-deacetoxy-(3-p-toluenesulfonyloxypropyl)-7-O-triethylsilylbaccatin III

Base Information

Chemical Name:[10R]-10-deacetoxy-(3-p-toluenesulfonyloxypropyl)-7-O-triethylsilylbaccatin III
CAS No.:325735-33-9
Molecular Formula:C₄₅H₆₂O₁₂SSi
Molecular Weight:855.132
Hs Code.:

Synonyms:[10R]-10-deacetoxy-(3-p-toluenesulfonyloxypropyl)-7-O-triethylsilylbaccatin III

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Chemical Property of [10R]-10-deacetoxy-(3-p-toluenesulfonyloxypropyl)-7-O-triethylsilylbaccatin III

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Technology Process of [10R]-10-deacetoxy-(3-p-toluenesulfonyloxypropyl)-7-O-triethylsilylbaccatin III

There total 1 articles about [10R]-10-deacetoxy-(3-p-toluenesulfonyloxypropyl)-7-O-triethylsilylbaccatin III which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 98-59-9
p-toluenesulfonyl chloride

: 204764-74-9
10-deacetoxy-10-hydroxypropyl-7-O-triethylsilylbaccatin III

: 325735-33-9
[10R]-10-deacetoxy-(3-p-toluenesulfonyloxypropyl)-7-O-triethylsilylbaccatin III

Guidance literature:: With dmap; TEA; In dichloromethane; at 20 ℃; for 18h;
DOI:10.3987/COM-00-9051

Reference yield: 82.0%

: 110-91-8,99108-56-2
morpholine

: 325735-33-9
[10R]-10-deacetoxy-(3-p-toluenesulfonyloxypropyl)-7-O-triethylsilylbaccatin III

: 325735-35-1
10-deacetoxy-10-(3-morpholinopropyl)-7-O-triethylsilylbaccatin III

Guidance literature:: In methanol; for 5h; Heating;
DOI:10.3987/COM-00-9051

Reference yield:

: 325735-33-9
[10R]-10-deacetoxy-(3-p-toluenesulfonyloxypropyl)-7-O-triethylsilylbaccatin III

: C₆₁H₉₂N₂O₁₃Si₂

Guidance literature:: Multi-step reaction with 6 steps

1.1: 332 mg / n-Bu₄NI / tetrahydrofuran; H₂O / 6 h / 20 °C

2.1: 312 mg / NaIO₄ / methanol; H₂O / 2 h / 0 °C

3.1: 37 percent / Na₂CO₃ / 1,2-dichloro-benzene / 4 h / Heating

4.1: 91 percent / NaH (60 percent oil suspension) / tetrahydrofuran / 2 h / 0 °C

5.1: OsO₄; NMO / tetrahydrofuran; H₂O / 2 h / 20 °C

5.2: 84 percent / NaIO₄ / tetrahydrofuran; H₂O / 24 h / 20 °C

6.1: H₂ / 10 percent Pd-C / methanol / 20 °C

With sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydride; sodium carbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; water; 1,2-dichloro-benzene;
DOI:10.3987/COM-00-9051