3β-acetoxy-22-[(trans-4-aminocyclohexyl)amino]-22-oxo-23,24-bisnor-chol-5-ene

Base Information

• Chemical Name: 3β-acetoxy-22-[(trans-4-aminocyclohexyl)amino]-22-oxo-23,24-bisnor-chol-5-ene
• CAS No.: 862719-29-7
• Molecular Formula: C₃₀H₄₈N₂O₃
• Molecular Weight: 484.723

Synonyms:3β-acetoxy-22-[(trans-4-aminocyclohexyl)amino]-22-oxo-23,24-bisnor-chol-5-ene

Chemical Property of 3β-acetoxy-22-[(trans-4-aminocyclohexyl)amino]-22-oxo-23,24-bisnor-chol-5-ene

Chemical Property:

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Technology Process of 3β-acetoxy-22-[(trans-4-aminocyclohexyl)amino]-22-oxo-23,24-bisnor-chol-5-ene

There total 2 articles about 3β-acetoxy-22-[(trans-4-aminocyclohexyl)amino]-22-oxo-23,24-bisnor-chol-5-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3β-acetoxybisnor-5-cholenic acid (1474-14-2) → 3β-acetoxy-22-[(trans-4-aminocyclohexyl)amino]-22-oxo-23,24-bisnor-chol-5-ene (862719-29-7)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-diisopropylethylamine; 2-(benzotriazol-1-yl)-1,1,3,3-tetramethyluronium BF₄ / dimethylformamide / 0.5 h / 20 °C

2: 0.450 g / dimethylformamide / 20 °C

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2005.06.012

Reference yield:

(S)-2-((3S,8S,9S,10R,13S,14S,17R)-3-Acetoxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-propionic acid benzotriazol-1-yl ester + trans-1,4-cyclohexyldiamine (2615-25-0) → 3β-acetoxy-22-[(trans-4-aminocyclohexyl)amino]-22-oxo-23,24-bisnor-chol-5-ene (862719-29-7)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmc.2005.06.012

Reference yield: 70.0%

3β-acetoxy-22-[(trans-4-aminocyclohexyl)amino]-22-oxo-23,24-bisnor-chol-5-ene (862719-29-7) → 3β-hydroxy-22-[(trans-4-aminocyclohexyl)amino]-22-oxo-23,24-bisnor-chol-5-ene

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; water;

DOI:10.1016/j.bmc.2005.06.012

upstream raw materials:

trans-1,4-cyclohexyldiamine

3β-acetoxybisnor-5-cholenic acid

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