Isobutyric acid (S)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetylamino]-propyl ester

Base Information

• Chemical Name: Isobutyric acid (S)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetylamino]-propyl ester
• CAS No.: 179472-02-7
• Molecular Formula: C₃₅H₃₉N₃O₈
• Molecular Weight: 629.71
• Mol file: 179472-02-7.mol

Synonyms:Isobutyric acid (S)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetylamino]-propyl ester

Chemical Property of Isobutyric acid (S)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetylamino]-propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Isobutyric acid (S)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetylamino]-propyl ester

There total 3 articles about Isobutyric acid (S)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetylamino]-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + Isobutyric acid (S)-3-hydroxy-2-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetylamino]-propyl ester (179472-01-6) → Isobutyric acid (S)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetylamino]-propyl ester (179472-02-7)

Guidance literature:

With TEA; In pyridine;

DOI:10.1016/0960-894X(96)00320-4

Reference yield:

Isobutyric acid (S)-3-benzyloxy-2-tert-butoxycarbonylamino-propyl ester (179472-05-0) → Isobutyric acid (S)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetylamino]-propyl ester (179472-02-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) trifluoroacetic acid, 2) 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride, N-methylmorpholine, 1-hydroxybenzotriazole / 1) CH₂Cl₂, 2) DMF

2: 91 percent / Pd(OH)2, cyclohexene, methanol

3: 88 percent / TEA / pyridine

With 4-methyl-morpholine; methanol; palladium dihydroxide; TEA; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; cyclohexene; In pyridine;

DOI:10.1016/0960-894X(96)00320-4

Reference yield:

Isobutyric acid (S)-3-benzyloxy-2-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetylamino]-propyl ester (179472-06-1) → Isobutyric acid (S)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetylamino]-propyl ester (179472-02-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / Pd(OH)2, cyclohexene, methanol

2: 88 percent / TEA / pyridine

With methanol; palladium dihydroxide; TEA; cyclohexene; In pyridine;

DOI:10.1016/0960-894X(96)00320-4

upstream raw materials:

4,4'-dimethoxytrityl chloride

Isobutyric acid (S)-3-hydroxy-2-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetylamino]-propyl ester

Isobutyric acid (S)-3-benzyloxy-2-tert-butoxycarbonylamino-propyl ester

Isobutyric acid (S)-3-benzyloxy-2-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetylamino]-propyl ester

Downstream raw materials:

N-{(R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-hydroxymethyl-ethyl}-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetamide