1-((6-((trans-4-(tert-butyl)cyclohexyl)oxy)-1,2,3,4-tetrahydronaphthalen-2-yl)methyl)piperidine-4-carboxylic acid

Base Information

Chemical Name:1-((6-((trans-4-(tert-butyl)cyclohexyl)oxy)-1,2,3,4-tetrahydronaphthalen-2-yl)methyl)piperidine-4-carboxylic acid
CAS No.:1393449-46-1
Molecular Formula:C₂₇H₄₁NO₃
Molecular Weight:427.627
Hs Code.:

Synonyms:1-((6-((trans-4-(tert-butyl)cyclohexyl)oxy)-1,2,3,4-tetrahydronaphthalen-2-yl)methyl)piperidine-4-carboxylic acid

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Chemical Property of 1-((6-((trans-4-(tert-butyl)cyclohexyl)oxy)-1,2,3,4-tetrahydronaphthalen-2-yl)methyl)piperidine-4-carboxylic acid

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Technology Process of 1-((6-((trans-4-(tert-butyl)cyclohexyl)oxy)-1,2,3,4-tetrahydronaphthalen-2-yl)methyl)piperidine-4-carboxylic acid

There total 4 articles about 1-((6-((trans-4-(tert-butyl)cyclohexyl)oxy)-1,2,3,4-tetrahydronaphthalen-2-yl)methyl)piperidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 3.4%

: 498-94-2
isonipecotic acid

: 1393449-45-0
6-((trans-4-(tert-butyl)cyclohexyl)oxy)-1,2,3,4-tetrahydronaphthalene-2-carbaldehyde

: 1393449-46-1
1-((6-((trans-4-(tert-butyl)cyclohexyl)oxy)-1,2,3,4-tetrahydronaphthalen-2-yl)methyl)piperidine-4-carboxylic acid

Guidance literature:: isonipecotic acid; 6-((trans-4-(tert-butyl)cyclohexyl)oxy)-1,2,3,4-tetrahydronaphthalene-2-carbaldehyde; In ethanol; for 2h; Reflux;

With sodium cyanoborohydride; In ethanol; for 1h; Reflux;

Reference yield:

: 53567-96-7
1,2,3,4-tetrahydro-6-n-hydroxynaphthalene-2-carboxylic acid

: 1393449-46-1
1-((6-((trans-4-(tert-butyl)cyclohexyl)oxy)-1,2,3,4-tetrahydronaphthalen-2-yl)methyl)piperidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid

2.1: triphenylphosphine / toluene / 0.33 h

2.2: 0 °C / Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 20 °C

3.2: 0.5 h

4.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C

5.1: ethanol / 2 h / Reflux

5.2: 1 h / Reflux

With lithium aluminium tetrahydride; Dess-Martin periodane; triphenylphosphine; sulfuric acid; In tetrahydrofuran; ethanol; dichloromethane; toluene;

Reference yield:

: 1393449-42-7
methyl 6-((trans-4-(tert-butyl)cyclohexyl)oxy)-1,2,3,4-tetrahydronaphthalene-2-carboxylate

: 1393449-46-1
1-((6-((trans-4-(tert-butyl)cyclohexyl)oxy)-1,2,3,4-tetrahydronaphthalen-2-yl)methyl)piperidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 20 °C

1.2: 0.5 h

2.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C

3.1: ethanol / 2 h / Reflux

3.2: 1 h / Reflux

With lithium aluminium tetrahydride; Dess-Martin periodane; In tetrahydrofuran; ethanol; dichloromethane;