ethyl 3-methoxy-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5,6,7,8,9-hexahydro-1H-pyrrolo[3,2-c]quinoline-2-carboxylate

Base Information

Chemical Name:ethyl 3-methoxy-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5,6,7,8,9-hexahydro-1H-pyrrolo[3,2-c]quinoline-2-carboxylate
CAS No.:1398508-19-4
Molecular Formula:C₂₄H₂₆N₂O₅
Molecular Weight:422.481
Hs Code.:

Synonyms:ethyl 3-methoxy-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5,6,7,8,9-hexahydro-1H-pyrrolo[3,2-c]quinoline-2-carboxylate

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Chemical Property of ethyl 3-methoxy-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5,6,7,8,9-hexahydro-1H-pyrrolo[3,2-c]quinoline-2-carboxylate

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Technology Process of ethyl 3-methoxy-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5,6,7,8,9-hexahydro-1H-pyrrolo[3,2-c]quinoline-2-carboxylate

There total 5 articles about ethyl 3-methoxy-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5,6,7,8,9-hexahydro-1H-pyrrolo[3,2-c]quinoline-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1398508-20-7
ethyl 3-hydroxy-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5,6,7,8,9-hexahydro-1H-pyrrolo[3,2-c]quinoline-2-carboxylate

: 77-78-1
dimethyl sulfate

: 1398508-19-4
ethyl 3-methoxy-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5,6,7,8,9-hexahydro-1H-pyrrolo[3,2-c]quinoline-2-carboxylate

Guidance literature:: With 10% Pd/C; hydrogen; In tetrahydrofuran; methanol; at 20 ℃; for 7h;
DOI:10.1016/j.bmc.2012.07.034

Reference yield:

: 1655-07-8
ethyl 2-oxocyclohexane carboxylate

: 1398508-19-4
ethyl 3-methoxy-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5,6,7,8,9-hexahydro-1H-pyrrolo[3,2-c]quinoline-2-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: ammonium acetate / methanol / 72 h / 20 °C

2: sodium ethanolate / ethanol; 5,5-dimethyl-1,3-cyclohexadiene / 19 h / 120 - 150 °C

3: trichlorophosphate / 1.5 h / 130 °C

4: sodium hydride / N,N-dimethyl acetamide; mineral oil / 15.5 h / 20 °C

5: triethylamine / ethanol / 48 h / Reflux

6: hydrogen; 10% Pd/C / methanol; tetrahydrofuran / 7 h / 20 °C

With ammonium acetate; 10% Pd/C; hydrogen; sodium ethanolate; sodium hydride; triethylamine; trichlorophosphate; In tetrahydrofuran; methanol; 5,5-dimethyl-1,3-cyclohexadiene; ethanol; N,N-dimethyl acetamide; mineral oil;
DOI:10.1016/j.bmc.2012.07.034

Reference yield:

: 1128-00-3
ethyl 2-aminocyclohex-1-ene-1-carboxylate

: 1398508-19-4
ethyl 3-methoxy-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-4,5,6,7,8,9-hexahydro-1H-pyrrolo[3,2-c]quinoline-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium ethanolate / ethanol; 5,5-dimethyl-1,3-cyclohexadiene / 19 h / 120 - 150 °C

2: trichlorophosphate / 1.5 h / 130 °C

3: sodium hydride / N,N-dimethyl acetamide; mineral oil / 15.5 h / 20 °C

4: triethylamine / ethanol / 48 h / Reflux

5: hydrogen; 10% Pd/C / methanol; tetrahydrofuran / 7 h / 20 °C

With 10% Pd/C; hydrogen; sodium ethanolate; sodium hydride; triethylamine; trichlorophosphate; In tetrahydrofuran; methanol; 5,5-dimethyl-1,3-cyclohexadiene; ethanol; N,N-dimethyl acetamide; mineral oil;
DOI:10.1016/j.bmc.2012.07.034