2-{6-(4-Chloro-benzyl)-2-[1-(5-methyl-[1,3,4]oxadiazol-2-yl)-piperidin-4-ylamino]-pyrimidin-4-yl}-propan-2-ol

Base Information

Chemical Name:2-{6-(4-Chloro-benzyl)-2-[1-(5-methyl-[1,3,4]oxadiazol-2-yl)-piperidin-4-ylamino]-pyrimidin-4-yl}-propan-2-ol
CAS No.:1329669-68-2
Molecular Formula:C₂₂H₂₇ClN₆O₂
Molecular Weight:442.948
Hs Code.:

Synonyms:2-{6-(4-Chloro-benzyl)-2-[1-(5-methyl-[1,3,4]oxadiazol-2-yl)-piperidin-4-ylamino]-pyrimidin-4-yl}-propan-2-ol

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Chemical Property of 2-{6-(4-Chloro-benzyl)-2-[1-(5-methyl-[1,3,4]oxadiazol-2-yl)-piperidin-4-ylamino]-pyrimidin-4-yl}-propan-2-ol

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Technology Process of 2-{6-(4-Chloro-benzyl)-2-[1-(5-methyl-[1,3,4]oxadiazol-2-yl)-piperidin-4-ylamino]-pyrimidin-4-yl}-propan-2-ol

There total 8 articles about 2-{6-(4-Chloro-benzyl)-2-[1-(5-methyl-[1,3,4]oxadiazol-2-yl)-piperidin-4-ylamino]-pyrimidin-4-yl}-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1329672-63-0
1-(5-methyl-[1,3,4]oxadiazol-2-yl)-piperidin-4-ylamine

: 1329672-61-8
2-[2-chloro-6-[(4-chlorophenyl)methyl]pyrimidin-4-yl]propan-2-ol

: 1329669-68-2
2-{6-(4-Chloro-benzyl)-2-[1-(5-methyl-[1,3,4]oxadiazol-2-yl)-piperidin-4-ylamino]-pyrimidin-4-yl}-propan-2-ol

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 160 ℃; for 6h;

Reference yield:

: 6299-85-0
2,6-dichloropyrimidine-4-carboxylic acid methyl ester

: 1329669-68-2
2-{6-(4-Chloro-benzyl)-2-[1-(5-methyl-[1,3,4]oxadiazol-2-yl)-piperidin-4-ylamino]-pyrimidin-4-yl}-propan-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 2.83 h / -78 - 0 °C

2: 4 h / 100 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 3 h / 50 °C / Inert atmosphere

4: water / toluene-4-sulfonic acid / tetrahydrofuran / 2 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 6 h / 160 °C

With water; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane;

Reference yield:

: 1329672-48-1
4-hydroxy-1-(5-methyl-[1,3,4]oxadiazol-2-yl)-1,2,5,6-tetrahydro-pyridine-3-carboxylic acid allyl ester potassium salt

: 1329669-68-2
2-{6-(4-Chloro-benzyl)-2-[1-(5-methyl-[1,3,4]oxadiazol-2-yl)-piperidin-4-ylamino]-pyrimidin-4-yl}-propan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / water

1.2: 1.08 h / 20 °C / Inert atmosphere

2.1: ammonium acetate / methanol / 2 h / Reflux; Inert atmosphere

3.1: hydrogen; ammonia / palladium 10% on activated carbon / methanol

4.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 6 h / 160 °C

With hydrogenchloride; ammonium acetate; ammonia; hydrogen; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In 1,4-dioxane; methanol; water;