5-(2-[1,3]dioxolan-2-yl-ethylsulfanyl)-1-phenyl-1H-tetrazole

Base Information

• Chemical Name: 5-(2-[1,3]dioxolan-2-yl-ethylsulfanyl)-1-phenyl-1H-tetrazole
• CAS No.: 904561-75-7
• Molecular Formula: C₁₂H₁₄N₄O₂S
• Molecular Weight: 278.335
• Mol file: 904561-75-7.mol

Synonyms:5-(2-[1,3]dioxolan-2-yl-ethylsulfanyl)-1-phenyl-1H-tetrazole

Chemical Property of 5-(2-[1,3]dioxolan-2-yl-ethylsulfanyl)-1-phenyl-1H-tetrazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(2-[1,3]dioxolan-2-yl-ethylsulfanyl)-1-phenyl-1H-tetrazole

There total 1 articles about 5-(2-[1,3]dioxolan-2-yl-ethylsulfanyl)-1-phenyl-1H-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-bromo-2-(2-ethyl)dioxolane (18742-02-4) + 1-Phenyl-1H-tetrazole-5-thiol (86-93-1) → 5-(2-[1,3]dioxolan-2-yl-ethylsulfanyl)-1-phenyl-1H-tetrazole (904561-75-7)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

DOI:10.1016/S0040-4039(99)00906-5

Reference yield: 89.0%

5-(2-[1,3]dioxolan-2-yl-ethylsulfanyl)-1-phenyl-1H-tetrazole (904561-75-7) → 5-(2-[1,3]dioxolan-2-yl-ethanesulfonyl)-1-phenyl-1H-tetrazole (232942-66-4)

Guidance literature:

With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 6h;

DOI:10.1016/S0040-4039(99)00906-5

Reference yield:

5-(2-[1,3]dioxolan-2-yl-ethylsulfanyl)-1-phenyl-1H-tetrazole (904561-75-7) → (2S,3S,4S)-3-hydroxy-6-methoxy-2-methyltetrahydro-2H-pyran-4-yl benzoate

Guidance literature:

Multi-step reaction with 5 steps

1.1: 89 percent / m-CPBA; NaHCO₃ / CH₂Cl₂ / 6 h / 20 °C

2.1: KHMDS / 1,2-dimethoxy-ethane / 14 h / -55 - 0 °C

3.1: AD-mix-α; MeSO2NH2 / 2-methyl-propan-2-ol; H2O / 37 h / 0 °C

4.1: DOWEX 50^Wx4 / 13 h / 20 °C

5.1: n-Bu₂SnO / toluene / 2 h / Heating

5.2: 85 percent / CHCl₃ / 8 h / 20 °C

With AD-mix-α; methanesulfonamide; DOWEX 50^Wx4; potassium hexamethylsilazane; di(n-butyl)tin oxide; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In 1,2-dimethoxyethane; dichloromethane; water; toluene; tert-butyl alcohol; 1.1: Oxidation / 2.1: Condensation / 3.1: dihydroxylation / 4.1: Hydrolysis / 5.1: Condensation / 5.2: Acylation;

DOI:10.1016/S0040-4039(99)00906-5

upstream raw materials:

2-bromo-2-(2-ethyl)dioxolane

1-Phenyl-1H-tetrazole-5-thiol

Downstream raw materials:

5-(2-[1,3]dioxolan-2-yl-ethanesulfonyl)-1-phenyl-1H-tetrazole

methyl 2,6-dideoxy-L-arabino-hexopyranoside

Benzoic acid (S)-1-((4R,5S)-3,5-dimethyl-2-oxo-oxazolidin-4-yl)-2-[1,3]dioxolan-2-yl-ethyl ester

Benzoyl-carbamic acid (S)-1-((2S,3S)-3-[1,3]dioxolan-2-ylmethyl-oxiranyl)-ethyl ester