tert-butyl N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-N1-(3-phenylpropyl)-L-α-glutaminate

Base Information

Chemical Name:tert-butyl N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-N1-(3-phenylpropyl)-L-α-glutaminate
CAS No.:920288-91-1
Molecular Formula:C₃₃H₃₈N₂O₅
Molecular Weight:542.675
Hs Code.:

Synonyms:tert-butyl N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-N1-(3-phenylpropyl)-L-α-glutaminate

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Chemical Property of tert-butyl N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-N1-(3-phenylpropyl)-L-α-glutaminate

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Technology Process of tert-butyl N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-N1-(3-phenylpropyl)-L-α-glutaminate

There total 1 articles about tert-butyl N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-N1-(3-phenylpropyl)-L-α-glutaminate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 2038-57-5
3-Phenylpropan-1-amine

: 71989-18-9
Fmoc-Glu(OtBu)-OH

: 920288-91-1
tert-butyl N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-N1-(3-phenylpropyl)-L-α-glutaminate

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 24.5h;

Reference yield: 100.0%

: 920288-91-1
tert-butyl N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-N1-(3-phenylpropyl)-L-α-glutaminate

: 920288-92-2
tert-butyl N1-(3-phenylpropyl)-L-α-glutaminate

Guidance literature:: With diethylamine; In acetonitrile; for 2.16667h;

Reference yield:

: 920288-91-1
tert-butyl N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-N1-(3-phenylpropyl)-L-α-glutaminate

: (S)-4-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-4-(3-phenyl-propylcarbamoyl)-butyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: piperidine / CH₂Cl₂ / 0.33 h

2: 1-ethyl-3-<3-(dimethylamino)propyl>carbodimide hydrochloride, 1-hydroxybenzotriazole, N-methylmorpholine / tetrahydrofuran / 16 h / Ambient temperature

With piperidine; 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0968-0896(96)00200-3