7-(2-(1H-imidazol-1-yl)-5-methylimidazo(1,5-b)pyridazin-7-yl)-1-phenyl-1-heptanone

Base Information

Chemical Name:7-(2-(1H-imidazol-1-yl)-5-methylimidazo(1,5-b)pyridazin-7-yl)-1-phenyl-1-heptanone
CAS No.:152534-26-4
Molecular Formula:C23H25 N5 O
Molecular Weight:387.48
Hs Code.:
Mol file:152534-26-4.mol

Synonyms:Imidazo[1,5-b]pyridazine,1-heptanone deriv.; Ipph

Suppliers and Price of 7-(2-(1H-imidazol-1-yl)-5-methylimidazo(1,5-b)pyridazin-7-yl)-1-phenyl-1-heptanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-(2-(1H-imidazol-1-yl)-5-methylimidazo(1,5-b)pyridazin-7-yl)-1-phenyl-1-heptanone

Chemical Property:

PSA：65.08000
Density:1.2g/cm³
LogP:4.59930

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 7-(2-(1H-imidazol-1-yl)-5-methylimidazo(1,5-b)pyridazin-7-yl)-1-phenyl-1-heptanone

There total 6 articles about 7-(2-(1H-imidazol-1-yl)-5-methylimidazo(1,5-b)pyridazin-7-yl)-1-phenyl-1-heptanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 68219-65-8
5-Benzamido-4-oxohexansaeureethylester

: 152534-26-4
7-(2-Imidazol-1-yl-5-methyl-imidazo[1,5-b]pyridazin-7-yl)-1-phenyl-heptan-1-one

Guidance literature:: Multi-step reaction with 6 steps

1: N₂H₄*H₂O / ethanol / Heating

2: Br₂, AcOH / 40 °C

3: 82 percent / 6M aq. HCl / 18 h / Heating

4: 61 percent / Et₃N / dimethylformamide / 24 h / 20 °C

5: 64 percent / POCl₃ / 1,2-dichloro-ethane / 3 h / Heating

6: 1.) NaH / 1.) DMF, 20 deg C, 30 min, 2.) DMF, 60 deg C, 18 h

With hydrogenchloride; bromine; sodium hydride; hydrazine hydrate; acetic acid; triethylamine; trichlorophosphate; In ethanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00076a005

Reference yield:

: 90175-94-3
N-1-(2,3-dihydro-3-oxopyridazin-6-yl)ethylamine hydrochloride

: 152534-26-4
7-(2-Imidazol-1-yl-5-methyl-imidazo[1,5-b]pyridazin-7-yl)-1-phenyl-heptan-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: 61 percent / Et₃N / dimethylformamide / 24 h / 20 °C

2: 64 percent / POCl₃ / 1,2-dichloro-ethane / 3 h / Heating

3: 1.) NaH / 1.) DMF, 20 deg C, 30 min, 2.) DMF, 60 deg C, 18 h

With sodium hydride; triethylamine; trichlorophosphate; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00076a005

Reference yield:

: 152534-40-2
(1'RS)-N-<1-(1,6-dihydro-6-oxo-3-pyridazinyl)ethyl>-8-oxo-8-phenyloctanamide

: 152534-26-4
7-(2-Imidazol-1-yl-5-methyl-imidazo[1,5-b]pyridazin-7-yl)-1-phenyl-heptan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 64 percent / POCl₃ / 1,2-dichloro-ethane / 3 h / Heating

2: 1.) NaH / 1.) DMF, 20 deg C, 30 min, 2.) DMF, 60 deg C, 18 h

With sodium hydride; trichlorophosphate; In 1,2-dichloro-ethane;
DOI:10.1021/jm00076a005