(N_α-carbobenzyloxy-L-2-amino-5-acryloylamino)pentanoylglycine

Base Information

• Chemical Name: (N_α-carbobenzyloxy-L-2-amino-5-acryloylamino)pentanoylglycine
• CAS No.: 366781-02-4
• Molecular Formula: C₁₈H₂₃N₃O₆
• Molecular Weight: 377.397
• Mol file: 366781-02-4.mol

Synonyms:(N_α-carbobenzyloxy-L-2-amino-5-acryloylamino)pentanoylglycine

Chemical Property of (N_α-carbobenzyloxy-L-2-amino-5-acryloylamino)pentanoylglycine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (N_α-carbobenzyloxy-L-2-amino-5-acryloylamino)pentanoylglycine

There total 3 articles about (N_α-carbobenzyloxy-L-2-amino-5-acryloylamino)pentanoylglycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(Nα-carbobenzyloxy-L-2-amino-5-acryloylamino)pentanoylglycine tert-butyl ester (366780-98-5) → (Nα-carbobenzyloxy-L-2-amino-5-acryloylamino)pentanoylglycine (366781-02-4)

Guidance literature:

With hydrogenchloride; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1016/S0968-0896(01)00292-9

Reference yield:

Nα-benzyloxycarbonyl-L-ornithine (2640-58-6) → (Nα-carbobenzyloxy-L-2-amino-5-acryloylamino)pentanoylglycine (366781-02-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 83 percent / Et₃N / methanol / 12 h / 0 - 20 °C

2.1: EDC*HCl; Et₃N / CH₂Cl₂ / 0.25 h

2.2: 85 percent / CH₂Cl₂ / 12 h / 20 °C

3.1: 100 percent / HCl gas / CH₂Cl₂ / 4 h / 20 °C

With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane;

DOI:10.1016/S0968-0896(01)00292-9

Reference yield:

Nα-carbobenzyloxy-L-2-amino-5-acryloylaminopentanoic acid (366780-94-1) → (Nα-carbobenzyloxy-L-2-amino-5-acryloylamino)pentanoylglycine (366781-02-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: EDC*HCl; Et₃N / CH₂Cl₂ / 0.25 h

1.2: 85 percent / CH₂Cl₂ / 12 h / 20 °C

2.1: 100 percent / HCl gas / CH₂Cl₂ / 4 h / 20 °C

With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane;

DOI:10.1016/S0968-0896(01)00292-9

upstream raw materials:

(N_α-carbobenzyloxy-L-2-amino-5-acryloylamino)pentanoylglycine tert-butyl ester

Nα-benzyloxycarbonyl-L-ornithine

N_α-carbobenzyloxy-L-2-amino-5-acryloylaminopentanoic acid