1-benzyloxymethyl-9-(4'-β-(dibenzylphosphono)methoxy-2',3'-dideoxy-2',3'-didehydro-β-D-erythrofuranosyl)hypoxanthine

Base Information

Chemical Name:1-benzyloxymethyl-9-(4'-β-(dibenzylphosphono)methoxy-2',3'-dideoxy-2',3'-didehydro-β-D-erythrofuranosyl)hypoxanthine
CAS No.:1232003-43-8
Molecular Formula:C₃₂H₃₁N₄O₇P
Molecular Weight:614.594
Hs Code.:

Synonyms:1-benzyloxymethyl-9-(4'-β-(dibenzylphosphono)methoxy-2',3'-dideoxy-2',3'-didehydro-β-D-erythrofuranosyl)hypoxanthine

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Chemical Property of 1-benzyloxymethyl-9-(4'-β-(dibenzylphosphono)methoxy-2',3'-dideoxy-2',3'-didehydro-β-D-erythrofuranosyl)hypoxanthine

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Technology Process of 1-benzyloxymethyl-9-(4'-β-(dibenzylphosphono)methoxy-2',3'-dideoxy-2',3'-didehydro-β-D-erythrofuranosyl)hypoxanthine

There total 3 articles about 1-benzyloxymethyl-9-(4'-β-(dibenzylphosphono)methoxy-2',3'-dideoxy-2',3'-didehydro-β-D-erythrofuranosyl)hypoxanthine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1232003-41-6
1-benzyloxymethyl-9-(2',3'-dideoxy-3',4'-didehydro-β-D-erythrofuranosyl)hypoxanthine

: 114790-35-1
dibenzyl hydroxymethylphosphonate

: 1232003-43-8
1-benzyloxymethyl-9-(4'-β-(dibenzylphosphono)methoxy-2',3'-dideoxy-2',3'-didehydro-β-D-erythrofuranosyl)hypoxanthine

Guidance literature:: 1-benzyloxymethyl-9-(2',3'-dideoxy-3',4'-didehydro-β-D-erythrofuranosyl)hypoxanthine; dibenzyl hydroxymethylphosphonate; With iodine(I) bromide; In dichloromethane; at -35 ℃; for 0.75h; Inert atmosphere;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1,4-dioxane; at 65 ℃; for 1.5h; stereoselective reaction; Inert atmosphere;
DOI:10.1039/b9nj00574a

Reference yield:

: 3'-acetyl-1-benzyloxymethyl-2'-deoxyinosine 5'-carboxylic acid

: 1232003-43-8
1-benzyloxymethyl-9-(4'-β-(dibenzylphosphono)methoxy-2',3'-dideoxy-2',3'-didehydro-β-D-erythrofuranosyl)hypoxanthine

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonia / methanol

2.1: N,N-dimethylformamide dineopentyl acetal / N,N-dimethyl-formamide / 6 h / 130 °C / Inert atmosphere

3.1: iodine(I) bromide / dichloromethane / 0.75 h / -35 °C / Inert atmosphere

3.2: 1.5 h / 65 °C / Inert atmosphere

With ammonia; iodine(I) bromide; N,N-dimethylformamide dineopentyl acetal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b9nj00574a

Reference yield:

: 1-benzyloxymethyl-2'-deoxyinosine 5'-carboxylic acid

: 1232003-43-8
1-benzyloxymethyl-9-(4'-β-(dibenzylphosphono)methoxy-2',3'-dideoxy-2',3'-didehydro-β-D-erythrofuranosyl)hypoxanthine

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N-dimethylformamide dineopentyl acetal / N,N-dimethyl-formamide / 6 h / 130 °C / Inert atmosphere

2.1: iodine(I) bromide / dichloromethane / 0.75 h / -35 °C / Inert atmosphere

2.2: 1.5 h / 65 °C / Inert atmosphere

With iodine(I) bromide; N,N-dimethylformamide dineopentyl acetal; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b9nj00574a