Ethyl-[3-methyl-1-phenyl-5-p-tolyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-(6Z)-ylidene]-amine

Base Information

• Chemical Name: Ethyl-[3-methyl-1-phenyl-5-p-tolyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-(6Z)-ylidene]-amine
• CAS No.: 114362-63-9
• Molecular Formula: C₂₁H₂₁N₅
• Molecular Weight: 343.431
• Mol file: 114362-63-9.mol

Synonyms:Ethyl-[3-methyl-1-phenyl-5-p-tolyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-(6Z)-ylidene]-amine

Chemical Property of Ethyl-[3-methyl-1-phenyl-5-p-tolyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-(6Z)-ylidene]-amine

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of Ethyl-[3-methyl-1-phenyl-5-p-tolyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-(6Z)-ylidene]-amine

There total 5 articles about Ethyl-[3-methyl-1-phenyl-5-p-tolyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-(6Z)-ylidene]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

4-<(N-p-tolylimino)methyl>-3-methyl-1-phenyl-5-<(triphenylphosphoranylidene)amino>-1H-pyrazole (114362-58-2) + ethyl isocyanate (109-90-0) → Ethyl-[3-methyl-1-phenyl-5-p-tolyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-(6Z)-ylidene]-amine (114362-63-9) + Triphenylphosphine oxide (791-28-6)

Guidance literature:

In dichloromethane; for 4h; Ambient temperature;

DOI:10.1016/S0040-4039(00)96536-5

Reference yield: 61.0%

4-<(N-p-tolylimino)methyl>-3-methyl-1-phenyl-5-<(triphenylphosphoranylidene)amino>-1H-pyrazole (114362-58-2) + ethyl isocyanate (109-90-0) → Ethyl-[3-methyl-1-phenyl-5-p-tolyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-(6Z)-ylidene]-amine (114362-63-9)

Guidance literature:

In dichloromethane; for 5h; Ambient temperature;

DOI:10.1021/jo00255a003

Reference yield:

5-chloro-4-formyl-3-methyl-1-phenyl-1H-pyrazole (947-95-5) → Ethyl-[3-methyl-1-phenyl-5-p-tolyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-(6Z)-ylidene]-amine (114362-63-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 67 percent / sodium azide / dimethylsulfoxide / 1 h / 60 °C

2: 96 percent / acetic acid / ethanol / 6 h / Ambient temperature

3: 81 percent / CH₂Cl₂ / 16 h / Ambient temperature

4: 61 percent / CH₂Cl₂ / 5 h / Ambient temperature

With sodium azide; acetic acid; In ethanol; dichloromethane; dimethyl sulfoxide;

DOI:10.1021/jo00255a003

upstream raw materials:

4-<(N-p-tolylimino)methyl>-3-methyl-1-phenyl-5-<(triphenylphosphoranylidene)amino>-1H-pyrazole

ethyl isocyanate

5-chloro-4-formyl-3-methyl-1-phenyl-1H-pyrazole

5-azido-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde