10-ethyl-5-methyl-5,10-dideazaaminopterin

Base Information

Chemical Name:10-ethyl-5-methyl-5,10-dideazaaminopterin
CAS No.:139504-90-8
Molecular Formula:C24H28 N6 O5
Molecular Weight:480.524
Hs Code.:
Mol file:139504-90-8.mol

Synonyms:Pyrido[2,3-d]pyrimidine,L-glutamic acid deriv.

Suppliers and Price of 10-ethyl-5-methyl-5,10-dideazaaminopterin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 10-ethyl-5-methyl-5,10-dideazaaminopterin

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
PSA：195.87000
Density:1.383g/cm³
LogP:2.53280

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 10-ethyl-5-methyl-5,10-dideazaaminopterin

There total 5 articles about 10-ethyl-5-methyl-5,10-dideazaaminopterin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 139504-89-5
diethyl N-<4-<1-<(2,4-diamino-5-methylpyrido<2,3-d>pyrimidin-6-yl)methyl>propyl>benzoyl>-L-glutamate

: 139504-90-8
N-<4-<1-<(2,4-diamino-5-methylpyrido<2,3-d>pyrimidin-6-yl)methyl>propyl>benzoyl>-L-glutamic acid

Guidance literature:: With sodium hydroxide; In methanol; at 20 - 25 ℃; for 40h;
DOI:10.1021/jm00094a011

Reference yield:

: 139537-66-9
methyl 4-<2-(2,4-diamino-5-methylpyrido<2,3-d>pyrimidin-6-yl)-1-ethylethenyl>benzoate

: 139504-90-8
N-<4-<1-<(2,4-diamino-5-methylpyrido<2,3-d>pyrimidin-6-yl)methyl>propyl>benzoyl>-L-glutamic acid

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / Pd/C / acetic acid / 0.5 h / Ambient temperature

2: 1 N aq. NaOH / dimethylsulfoxide

3: 1.) N-methylmorpholine, (EtO)2POCN / 1.) DMSO, from 20 to 25 deg C, 2 h, 2.) DMSO, fom 20 to 25 deg C, 62 h

4: 76 percent / 1 N aq. NaOH / methanol / 40 h / 20 - 25 °C

With 4-methyl-morpholine; sodium hydroxide; diethyl cyanophosphonate; hydrogen; palladium on activated charcoal; In methanol; acetic acid; dimethyl sulfoxide;
DOI:10.1021/jm00094a011

Reference yield:

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 139504-90-8
N-<4-<1-<(2,4-diamino-5-methylpyrido<2,3-d>pyrimidin-6-yl)methyl>propyl>benzoyl>-L-glutamic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) N-methylmorpholine, (EtO)2POCN / 1.) DMSO, from 20 to 25 deg C, 2 h, 2.) DMSO, fom 20 to 25 deg C, 62 h

2: 76 percent / 1 N aq. NaOH / methanol / 40 h / 20 - 25 °C

With 4-methyl-morpholine; sodium hydroxide; diethyl cyanophosphonate; In methanol;
DOI:10.1021/jm00094a011