(-)-9-(1R,2R-Pseudoephedrinyl)-(10S)-(trimethylsilyl)-9-borabicyclo[3.3.2]decane

Base Information

• Chemical Name: (-)-9-(1R,2R-Pseudoephedrinyl)-(10S)-(trimethylsilyl)-9-borabicyclo[3.3.2]decane
• CAS No.: 856676-11-4
• Molecular Formula: C₂₂H₃₈BNOSi
• Molecular Weight: 371.446
• Mol file: 856676-11-4.mol

Synonyms:(1R,2R)-N-methyl-1-phenyl-1-(((1S,5S,10R)-10-(trimethylsilyl)-9-borabicyclo[3.3.2]decan-9-yl)oxy)propan-2-amine

Chemical Property of (-)-9-(1R,2R-Pseudoephedrinyl)-(10S)-(trimethylsilyl)-9-borabicyclo[3.3.2]decane

Chemical Property:

• Melting Point: 135-148?°C

Purity/Quality:

(-)-9-(1R,2R-PSEUDOEPHEDRINYL)-(10S)-(TRIMETHYLSILYL)-9-BORABICYCLO[3.3.2]DECANE 95.00% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

Useful:

Technology Process of (-)-9-(1R,2R-Pseudoephedrinyl)-(10S)-(trimethylsilyl)-9-borabicyclo[3.3.2]decane

There total 14 articles about (-)-9-(1R,2R-Pseudoephedrinyl)-(10S)-(trimethylsilyl)-9-borabicyclo[3.3.2]decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-9-[(S)-1-((E)-Propenyl)-2-trimethylsilanyl-buta-2,3-dienyloxy]-10-trimethylsilanyl-9-bora-bicyclo[3.3.2]decane (872359-77-8) + (1R,2R)-pseudoephedrine (321-97-1,7009-81-6,90-83-5,6912-63-6) → (1R,2R)-N-methyl-1-phenyl-1-(((1S,5S,10R)-10-(trimethylsilyl)-9-borabicyclo[3.3.2]decan-9-yl)oxy)propan-2-amine (856676-11-4) + (+)-(4S)-(E)-3-(trimethylsilyl)-1,2,5-heptatrien-4-ol (872359-78-9)

Guidance literature:

In acetonitrile; at 81 ℃; for 10h;

DOI:10.1021/ol051886k

Reference yield:

(S)-9-((R)-1-Propyl-2-trimethylsilanyl-buta-2,3-dienyloxy)-10-trimethylsilanyl-9-bora-bicyclo[3.3.2]decane + (1R,2R)-pseudoephedrine (321-97-1,7009-81-6,90-83-5,6912-63-6) → (1R,2R)-N-methyl-1-phenyl-1-(((1S,5S,10R)-10-(trimethylsilyl)-9-borabicyclo[3.3.2]decan-9-yl)oxy)propan-2-amine (856676-11-4) + (-)-(4R)-3-(trimethylsilyl)-1,2-heptadien-4-ol

Guidance literature:

In acetonitrile; at 81 ℃; for 9h;

DOI:10.1021/ol051886k

Reference yield:

(S)-9-((R)-1-Isopropyl-2-trimethylsilanyl-buta-2,3-dienyloxy)-10-trimethylsilanyl-9-bora-bicyclo[3.3.2]decane + (1R,2R)-pseudoephedrine (321-97-1,7009-81-6,90-83-5,6912-63-6) → (1R,2R)-N-methyl-1-phenyl-1-(((1S,5S,10R)-10-(trimethylsilyl)-9-borabicyclo[3.3.2]decan-9-yl)oxy)propan-2-amine (856676-11-4) + (-)-(3R)-2-methyl-4-(trimethylsilyl)-4,5-hexadien-3-ol

Guidance literature:

In acetonitrile; at 81 ℃; for 10h;

DOI:10.1021/ol051886k

upstream raw materials:

(+)-(10S)-B-methoxy-10-trimethylsilyl-9-borabicyclo[3.3.2]decane

(1R,2R)-pseudoephedrine

(R)-9-[(S)-1-((E)-Propenyl)-2-trimethylsilanyl-buta-2,3-dienyloxy]-10-trimethylsilanyl-9-bora-bicyclo[3.3.2]decane

(R)-10-Trimethylsilanyl-9-(3-trimethylsilanyl-prop-2-ynyl)-9-bora-bicyclo[3.3.2]decane

Downstream raw materials:

(S)-9-((S)-1-Phenyl-but-3-enyloxy)-10-trimethylsilanyl-9-bora-bicyclo[3.3.2]decane

(+)-(1R)-1-phenyl-2-(trimethylsilyl)-2,3-butadien-1-ol

(S)-10-Trimethylsilanyl-9-(3-trimethylsilanyl-prop-2-ynyl)-9-bora-bicyclo[3.3.2]decane

(1R,2R)-pseudoephedrine

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