1,1-dimethylethyl 4-[4-{2-chloro-3-[(propylsulfonyl)amino]phenyl}-5-(2-amino-4-pyrimidinyl)-1,3-thiazol-2-yl]-1-piperazinecarboxylate

Base Information

Chemical Name:1,1-dimethylethyl 4-[4-{2-chloro-3-[(propylsulfonyl)amino]phenyl}-5-(2-amino-4-pyrimidinyl)-1,3-thiazol-2-yl]-1-piperazinecarboxylate
CAS No.:1307272-75-8
Molecular Formula:C₂₅H₃₂ClN₇O₄S₂
Molecular Weight:594.159
Hs Code.:

Synonyms:1,1-dimethylethyl 4-[4-{2-chloro-3-[(propylsulfonyl)amino]phenyl}-5-(2-amino-4-pyrimidinyl)-1,3-thiazol-2-yl]-1-piperazinecarboxylate

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Chemical Property of 1,1-dimethylethyl 4-[4-{2-chloro-3-[(propylsulfonyl)amino]phenyl}-5-(2-amino-4-pyrimidinyl)-1,3-thiazol-2-yl]-1-piperazinecarboxylate

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Technology Process of 1,1-dimethylethyl 4-[4-{2-chloro-3-[(propylsulfonyl)amino]phenyl}-5-(2-amino-4-pyrimidinyl)-1,3-thiazol-2-yl]-1-piperazinecarboxylate

There total 7 articles about 1,1-dimethylethyl 4-[4-{2-chloro-3-[(propylsulfonyl)amino]phenyl}-5-(2-amino-4-pyrimidinyl)-1,3-thiazol-2-yl]-1-piperazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 120100-15-4
methyl 3-amino-2-chlorobenzoate

: 1307272-75-8
1,1-dimethylethyl 4-[4-{2-chloro-3-[(propylsulfonyl)amino]phenyl}-5-(2-amino-4-pyrimidinyl)-1,3-thiazol-2-yl]-1-piperazinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / 6.5 h / 0 - 30 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / -30 - -10 °C / Inert atmosphere

2.2: -10 - 20 °C / Inert atmosphere

3.1: N-Bromosuccinimide / ISOPROPYLAMIDE / 2 h / 20 °C / Inert atmosphere

3.2: 96 h / 20 °C / Inert atmosphere

4.1: ammonium hydroxide / water / 2 h / 90 °C / Inert atmosphere; Microwave irradiation

With pyridine; ammonium hydroxide; N-Bromosuccinimide; lithium hexamethyldisilazane; In tetrahydrofuran; ISOPROPYLAMIDE; water;

Reference yield:

: 53553-14-3
2-chloro-3-nitrobenzoic acid methyl ester

: 1307272-75-8
1,1-dimethylethyl 4-[4-{2-chloro-3-[(propylsulfonyl)amino]phenyl}-5-(2-amino-4-pyrimidinyl)-1,3-thiazol-2-yl]-1-piperazinecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / methanol / 3.5 h / 25 °C / 2585.81 Torr / Inert atmosphere

2.1: pyridine / 6.5 h / 0 - 30 °C / Inert atmosphere

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / -30 - -10 °C / Inert atmosphere

3.2: -10 - 20 °C / Inert atmosphere

4.1: N-Bromosuccinimide / ISOPROPYLAMIDE / 2 h / 20 °C / Inert atmosphere

4.2: 96 h / 20 °C / Inert atmosphere

5.1: ammonium hydroxide / water / 2 h / 90 °C / Inert atmosphere; Microwave irradiation

With pyridine; ammonium hydroxide; N-Bromosuccinimide; hydrogen; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; ISOPROPYLAMIDE; water;

Reference yield:

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 1307272-75-8
1,1-dimethylethyl 4-[4-{2-chloro-3-[(propylsulfonyl)amino]phenyl}-5-(2-amino-4-pyrimidinyl)-1,3-thiazol-2-yl]-1-piperazinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / water; tetrahydrofuran / 20 °C / Inert atmosphere

2.1: N-Bromosuccinimide / ISOPROPYLAMIDE / 2 h / 20 °C / Inert atmosphere

2.2: 96 h / 20 °C / Inert atmosphere

3.1: ammonium hydroxide / water / 2 h / 90 °C / Inert atmosphere; Microwave irradiation

With hydrogenchloride; ammonium hydroxide; N-Bromosuccinimide; In tetrahydrofuran; ISOPROPYLAMIDE; water;