Technology Process of tert-butyl 2-((2S,3R)-1,3-bis(benzyloxy)-1-oxobutan-2-yl)-6-methyl-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate
There total 14 articles about tert-butyl 2-((2S,3R)-1,3-bis(benzyloxy)-1-oxobutan-2-yl)-6-methyl-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
di-isopropyl azodicarboxylate; triphenylphosphine;
In
tetrahydrofuran;
at 20 ℃;
for 8h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: hydrogenchloride / methanol / 12 h / Inert atmosphere
2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 0 - 20 °C
3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 8 h / 20 °C
With
hydrogenchloride; di-isopropyl azodicarboxylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine;
In
tetrahydrofuran; methanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: thionyl chloride / 16 h / 0 - 20 °C
2.1: triethylamine; dmap / dichloromethane / 16 h / 0 - 20 °C
3.1: tetrahydrofuran; diethyl ether / 2 h / 0 °C / Inert atmosphere
4.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C
5.1: hydrogen; palladium 10% on activated carbon / ethanol / 16 h
6.1: triethylamine; dmap / dichloromethane / 16 h / 0 - 20 °C
7.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 °C
7.2: 2 h / -30 °C
8.1: sodium hydroxide / water; methanol; tetrahydrofuran / 8 h / 65 °C
9.1: hydrogen; palladium 10% on activated carbon / methanol / 16 h / 20 °C
10.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 0 - 20 °C
11.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 8 h / 20 °C
With
dmap; thionyl chloride; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water;
