7-(benzyloxy)-N-(3-chloro-4-flurophenyl)-6-methoxyquinazoline-4-amine

Base Information

• Chemical Name: 7-(benzyloxy)-N-(3-chloro-4-flurophenyl)-6-methoxyquinazoline-4-amine
• CAS No.: 451494-90-9
• Molecular Formula: C₂₂H₁₇ClFN₃O₂
• Molecular Weight: 409.847
• Mol file: 451494-90-9.mol

Synonyms:7-(benzyloxy)-N-(3-chloro-4-flurophenyl)-6-methoxyquinazoline-4-amine

Chemical Property of 7-(benzyloxy)-N-(3-chloro-4-flurophenyl)-6-methoxyquinazoline-4-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-(benzyloxy)-N-(3-chloro-4-flurophenyl)-6-methoxyquinazoline-4-amine

There total 7 articles about 7-(benzyloxy)-N-(3-chloro-4-flurophenyl)-6-methoxyquinazoline-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-chloro-4-fluorophenylamine (367-21-5) + 7-benzyloxy-4-chloro-6-methoxyquinazoline (162364-72-9) → 7-(benzyloxy)-N-(3-chloro-4-flurophenyl)-6-methoxyquinazoline-4-amine (451494-90-9)

Guidance literature:

In isopropyl alcohol; for 4h; Reflux;

DOI:10.1007/s12272-017-0977-z

Reference yield:

7-benzyloxy-6-methoxy-3,4-dihydroquinazolin-4-one (179688-01-8) → 7-(benzyloxy)-N-(3-chloro-4-flurophenyl)-6-methoxyquinazoline-4-amine (451494-90-9)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / 1,2-dichloro-ethane / 1 h / 85 °C

2: isopropyl alcohol / 80 - 90 °C / Inert atmosphere

With trichlorophosphate; In 1,2-dichloro-ethane; isopropyl alcohol;

Reference yield:

4-hydroxy-3-methoxybenzoic acid methyl ester (3943-74-6) → 7-(benzyloxy)-N-(3-chloro-4-flurophenyl)-6-methoxyquinazoline-4-amine (451494-90-9)

Guidance literature:

Multi-step reaction with 6 steps

1: potassium carbonate / acetonitrile / 2 h / 90 °C / Inert atmosphere

2: nitric acid; acetic acid / 16 h / -5 - 25 °C / Cooling with ice

3: ammonium chloride; iron / water; methanol / 0.5 h / 80 °C / Inert atmosphere

4: ammonium formate / formamide / 3 h / 160 °C / Inert atmosphere

5: trichlorophosphate / 1,2-dichloro-ethane / 1 h / 85 °C

6: isopropyl alcohol / 80 - 90 °C / Inert atmosphere

With nitric acid; ammonium formate; iron; potassium carbonate; ammonium chloride; acetic acid; trichlorophosphate; In methanol; water; formamide; 1,2-dichloro-ethane; isopropyl alcohol; acetonitrile;

upstream raw materials:

7-benzyloxy-6-methoxy-3,4-dihydroquinazolin-4-one

3-chloro-4-fluorophenylamine

7-benzyloxy-4-chloro-6-methoxyquinazoline

4-hydroxy-3-methoxybenzoic acid methyl ester

Downstream raw materials:

4-((3-chloro-4-fluorophenyl)amino)-6-methoxyquinazolin-7-ol