ethyl 4-<(5-amino-2-hydroxyphenyl)methyl>-1-piperazinecarboxylate dihydrochloride

Base Information

Chemical Name:ethyl 4-<(5-amino-2-hydroxyphenyl)methyl>-1-piperazinecarboxylate dihydrochloride
CAS No.:86177-10-8
Molecular Formula:C₁₄H₂₁N₃O₃*2ClH
Molecular Weight:352.261
Hs Code.:

Synonyms:ethyl 4-<(5-amino-2-hydroxyphenyl)methyl>-1-piperazinecarboxylate dihydrochloride

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Chemical Property of ethyl 4-<(5-amino-2-hydroxyphenyl)methyl>-1-piperazinecarboxylate dihydrochloride

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Technology Process of ethyl 4-<(5-amino-2-hydroxyphenyl)methyl>-1-piperazinecarboxylate dihydrochloride

There total 3 articles about ethyl 4-<(5-amino-2-hydroxyphenyl)methyl>-1-piperazinecarboxylate dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 4-(2-Hydroxy-5-nitro-benzyl)-piperazine-1-carboxylic acid ethyl ester

: 1-piperazinecarboxylic acid hydrochloride

: 86177-10-8
ethyl 4-<(5-amino-2-hydroxyphenyl)methyl>-1-piperazinecarboxylate dihydrochloride

Guidance literature:: With hydrogenchloride; hydrogen; nickel; In isopropyl alcohol; at 27 ℃; for 0.5h; under 2637.5 Torr;
DOI:10.1021/jm00363a010

Reference yield:

: 120-43-4
4-ethoxycarbonylpiperazine

: 86177-10-8
ethyl 4-<(5-amino-2-hydroxyphenyl)methyl>-1-piperazinecarboxylate dihydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran; H₂O / 20 h / Heating

2: 90 percent / H₂, HCl / Raney nickel / propan-2-ol / 0.5 h / 27 °C / 2637.5 Torr

With hydrogenchloride; hydrogen; nickel; In tetrahydrofuran; water; isopropyl alcohol;
DOI:10.1021/jm00363a010

Reference yield:

: 2973-19-5
2-hydroxy-5-nitrobenzyl chloride

: 86177-10-8
ethyl 4-<(5-amino-2-hydroxyphenyl)methyl>-1-piperazinecarboxylate dihydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran; H₂O / 20 h / Heating

2: 90 percent / H₂, HCl / Raney nickel / propan-2-ol / 0.5 h / 27 °C / 2637.5 Torr

With hydrogenchloride; hydrogen; nickel; In tetrahydrofuran; water; isopropyl alcohol;
DOI:10.1021/jm00363a010