3-Amino-4-phenyl-6-thiophen-2-yl-thieno[2,3-b]pyridine-2-carboxylic acid [1-(4-chloro-phenyl)-meth-(E)-ylidene]-hydrazide

Base Information

• Chemical Name: 3-Amino-4-phenyl-6-thiophen-2-yl-thieno[2,3-b]pyridine-2-carboxylic acid [1-(4-chloro-phenyl)-meth-(E)-ylidene]-hydrazide
• CAS No.: 847976-37-8
• Molecular Formula: C₂₅H₁₇ClN₄OS₂
• Molecular Weight: 489.021
• Mol file: 847976-37-8.mol

Synonyms:3-Amino-4-phenyl-6-thiophen-2-yl-thieno[2,3-b]pyridine-2-carboxylic acid [1-(4-chloro-phenyl)-meth-(E)-ylidene]-hydrazide

Chemical Property of 3-Amino-4-phenyl-6-thiophen-2-yl-thieno[2,3-b]pyridine-2-carboxylic acid [1-(4-chloro-phenyl)-meth-(E)-ylidene]-hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Amino-4-phenyl-6-thiophen-2-yl-thieno[2,3-b]pyridine-2-carboxylic acid [1-(4-chloro-phenyl)-meth-(E)-ylidene]-hydrazide

There total 7 articles about 3-Amino-4-phenyl-6-thiophen-2-yl-thieno[2,3-b]pyridine-2-carboxylic acid [1-(4-chloro-phenyl)-meth-(E)-ylidene]-hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(3-Cyano-4-phenyl-6-thiophen-2-yl-pyridin-2-ylsulfanyl)-acetic acid [1-(4-chloro-phenyl)-meth-(E)-ylidene]-hydrazide (847976-34-5) → 3-Amino-4-phenyl-6-thiophen-2-yl-thieno[2,3-b]pyridine-2-carboxylic acid [1-(4-chloro-phenyl)-meth-(E)-ylidene]-hydrazide (847976-37-8)

Guidance literature:

With sodium ethanolate; In ethanol; for 0.25h; Heating;

DOI:10.1080/10426500490467147

Reference yield:

3-phenyl-1-thiophen-2-yl-propenone (3988-77-0,39078-33-6,69656-36-6) → 3-Amino-4-phenyl-6-thiophen-2-yl-thieno[2,3-b]pyridine-2-carboxylic acid [1-(4-chloro-phenyl)-meth-(E)-ylidene]-hydrazide (847976-37-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 43 percent / piperidine / ethanol / 4 h / Heating

2: 95 percent / sodium acetate trihydrate / ethanol / 2 h / Heating

3: 86 percent / N₂H₄*H₂O / ethanol / 4 h / Heating

4: 90 percent / ethanol / 4 h / Heating

5: 95 percent / NaOEt / ethanol / 0.25 h / Heating

With piperidine; sodium ethanolate; sodium acetate; hydrazine hydrate; In ethanol; 5: Thorpe-Ziegler cyclization;

DOI:10.1080/10426500490467147

Reference yield:

4-phenyl-6-(thiophen-2-yl)-2-thioxo-1,2-dihydropyridine-3-carbonitrile (82127-11-5) → 3-Amino-4-phenyl-6-thiophen-2-yl-thieno[2,3-b]pyridine-2-carboxylic acid [1-(4-chloro-phenyl)-meth-(E)-ylidene]-hydrazide (847976-37-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 95 percent / sodium acetate trihydrate / ethanol / 2 h / Heating

2: 86 percent / N₂H₄*H₂O / ethanol / 4 h / Heating

3: 90 percent / ethanol / 4 h / Heating

4: 95 percent / NaOEt / ethanol / 0.25 h / Heating

With sodium ethanolate; sodium acetate; hydrazine hydrate; In ethanol; 4: Thorpe-Ziegler cyclization;

DOI:10.1080/10426500490467147

upstream raw materials:

4-chlorobenzaldehyde

3-amino-4-phenyl-6-thiophen-2-yl-thieno[2,3-b]pyridine-2-carboxylic acid hydrazide

(3-Cyano-4-phenyl-6-thiophen-2-yl-pyridin-2-ylsulfanyl)-acetic acid [1-(4-chloro-phenyl)-meth-(E)-ylidene]-hydrazide

3-phenyl-1-thiophen-2-yl-propenone