tert-butyl (S)-2-[(S)-N-allyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanamido]-3-phenylpropanoate

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Chemical Name:tert-butyl (S)-2-[(S)-N-allyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanamido]-3-phenylpropanoate
CAS No.:1259541-22-4
Molecular Formula:C₃₄H₃₈N₂O₅
Molecular Weight:554.686
Hs Code.:

Synonyms:tert-butyl (S)-2-[(S)-N-allyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanamido]-3-phenylpropanoate

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Chemical Property of tert-butyl (S)-2-[(S)-N-allyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanamido]-3-phenylpropanoate

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Technology Process of tert-butyl (S)-2-[(S)-N-allyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanamido]-3-phenylpropanoate

There total 1 articles about tert-butyl (S)-2-[(S)-N-allyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanamido]-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 35661-39-3,136132-75-7
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

: N-allyl-(S)-phenylalanine

: 1259541-22-4
tert-butyl (S)-2-[(S)-N-allyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanamido]-3-phenylpropanoate

Guidance literature:: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 20 ℃; for 0.416667h; Inert atmosphere;

N-allyl-(S)-phenylalanine; In dichloromethane; at 42 ℃; for 48h; Inert atmosphere;
DOI:10.1055/s-0032-1316758

Reference yield:

: 1259541-22-4
tert-butyl (S)-2-[(S)-N-allyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanamido]-3-phenylpropanoate

: tert-butyl (S)-2-[(S)-N-allyl-2-aminopropanamido]-3-phenylpropanoate

Guidance literature:: With diethylamine; In dichloromethane; at 20 ℃; for 3.5h;
DOI:10.1055/s-0032-1316758

Reference yield:

: 1259541-22-4
tert-butyl (S)-2-[(S)-N-allyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanamido]-3-phenylpropanoate

: (S)-2-[(3S,6S,Z)-6-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methyl-2,5-dioxo-3,4,5,6,7,10-hexahydro-1,4-diazecin-1(2H)-yl]-3-phenylpropanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: diethylamine / dichloromethane / 3.5 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; diisopropyl-carbodiimide / tetrahydrofuran / 0.42 h / 20 °C / Inert atmosphere

2.2: 12 h / 20 °C / Inert atmosphere

3.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / 3.5 h / Inert atmosphere; Reflux

4.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; benzotriazol-1-ol; diethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; diisopropyl-carbodiimide; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1055/s-0032-1316758