methyl 6-(2,6-difluoro-4-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)-5-fluoropicolinate

Base Information

Chemical Name:methyl 6-(2,6-difluoro-4-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)-5-fluoropicolinate
CAS No.:1395282-15-1
Molecular Formula:C₁₈H₁₆F₃NO₄
Molecular Weight:367.325
Hs Code.:

Synonyms:methyl 6-(2,6-difluoro-4-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)-5-fluoropicolinate

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Chemical Property of methyl 6-(2,6-difluoro-4-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)-5-fluoropicolinate

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Technology Process of methyl 6-(2,6-difluoro-4-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)-5-fluoropicolinate

There total 5 articles about methyl 6-(2,6-difluoro-4-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)-5-fluoropicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 2081-44-9
Tetrahydro-pyran-4-ol

: 1355011-30-1
methyl 6-(2,6-difluoro-4-hydroxyphenyl)-5-fluoropyridine-2-carboxylate

: 1395282-15-1
methyl 6-(2,6-difluoro-4-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)-5-fluoropicolinate

Guidance literature:: Tetrahydro-pyran-4-ol; With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; for 0.166667h;

methyl 6-(2,6-difluoro-4-hydroxyphenyl)-5-fluoropyridine-2-carboxylate; In tetrahydrofuran; at 20 ℃;

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran;

Reference yield: 77.0%

: 1210419-26-3
methyl 6-bromo-5-fluoropyridine-2-carboxylate

: 1395282-24-2
2-(2,6-difluoro-4-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1395282-15-1
methyl 6-(2,6-difluoro-4-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)-5-fluoropicolinate

Guidance literature:: With potassium fluoride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; In tetrahydrofuran; water; at 100 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

Reference yield: 77.0%

: 1395282-15-1
methyl 6-(2,6-difluoro-4-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)-5-fluoropicolinate

Guidance literature:: With potassium fluoride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; In tetrahydrofuran; water; at 80 ℃; for 1h; Inert atmosphere;