Sodium Thiosulfate

Base Information

• Chemical Name: Sodium Thiosulfate
• CAS No.: 7772-98-7
• Deprecated CAS: 13773-27-8,220945-47-1,1374442-73-5,2554533-79-6,2585669-88-9,1374442-73-5,220945-47-1
• Molecular Formula: Na2S2O3
• Molecular Weight: 158.11
• Hs Code.: 2830909000
• European Community (EC) Number: 231-867-5
• ICSC Number: 1138
• UNII: L0IYT1O31N
• DSSTox Substance ID: DTXSID9042417
• Nikkaji Number: J47.986A
• Wikipedia: Sodium thiosulfate,Sodium_thiosulfate
• Wikidata: Q339866
• NCI Thesaurus Code: C1230,C84170
• RXCUI: 36726,1807514
• ChEMBL ID: CHEMBL3753202
• Mol file: 7772-98-7.mol

Synonyms:pentahydrate of sodium thiosulfate;sodium thiosulfate;sodium thiosulfate (USAN);sodium thiosulfate anhydrous;sodium thiosulfate pentahydrate;thiosulfuric acid, disodium salt

Chemical Property of Sodium Thiosulfate

Chemical Property:

• Appearance/Colour: White powder
• Melting Point: 48.°C
• Boiling Point: 100 °C
• PSA: 103.66000
• Density: 1.667 g/cm³
• LogP: 0.50980
• Water Solubility.: Soluble in water
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 157.90842477
• Heavy Atom Count: 7
• Complexity: 82.6

Purity/Quality:

>98% ^*data from raw suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Safety Statements: S24/25:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Other Classes -> Sulfur Compounds
• Canonical SMILES: [O-]S(=O)(=S)[O-].[Na+].[Na+]
• Recent ClinicalTrials: Individualized Response Assessment to Heated Intraperitoneal Chemotherapy (HIPEC) for the Treatment of Peritoneal Carcinomatosis From Ovarian, Colorectal, Appendiceal, or Peritoneal Mesothelioma Histologies
• Recent EU Clinical Trials: Hydrogen sulfate guided therapy with STS for COVID-19 patients in need of critical care: The H4COVID open-label, randomized, triple-arm trial
• Recent NIPH Clinical Trials: Phase I/II trial of cisplatin-based transarterial infusion and concomitant radiotherapy for advanced hepatocellular carcinoma with portal vein tumor thrombosis
• Inhalation Risk: A nuisance-causing concentration of airborne particles can be reached quickly when dispersed.
• Description: Sodium Thiosulfate, also known as sodium hyposulfite or sodium soda, manifests as colorless and transparent monoclinic crystals. It exhibits solubility in water and is nearly neutral in aqueous solution. Insoluble in ethanol and deliquescent in humid air, sodium thiosulfate is prone to weathering in air temperatures exceeding 33°C. Additionally, it possesses reducing properties, dissolves silver halide, and undergoes decomposition into sodium sulfide and sodium sulfate when heated.
• Uses: Widely used across various industries, sodium thiosulfate serves as a fixative in photography, a detergent and disinfectant in the pharmaceutical field, and a neutralizing agent for nitrogen-containing tail gas. Moreover, it finds applications as a mordant, bleaching agent, and dechlorinating agent, contributing to diverse processes such as tanning, pulp bleaching, and metal extraction. Notably, sodium thiosulfate acts as an antidote for cyanide poisoning by forming non-toxic thiocyanate compounds, demonstrating its versatility in pharmaceutical and medical applications.
• Medical Uses: Sodium Thiosulfate serves as a treatment for conditions such as calciphylaxis/calcific uremic arteriolopathy, where it exhibits antioxidant properties and aids in reducing pain and subcutaneous calcifications.^[1],^[2] Moreover, sodium thiosulfate serves as an otoprotective agent in chemotherapy, reducing the incidence and severity of cisplatin-induced hearing loss in patients undergoing treatment for conditions like hepatoblastoma.^[3] Furthermore, it plays a crucial role in treating cyanide poisoning and managing side effects of hemodialysis and chemotherapy.^[4]
• Other Uses: Sodium Thiosulfate acts as a fixative, stabilizing developed images by dissolving unexposed silver halide. In metallurgy, it offers an alternative to cyanidation for gold leaching processes. Additionally, it serves as an antichlorine in bleaching and aids in wastewater purification. In leather production, it reduces dichromate, contributing to the production process. Moreover, in analytical chemistry, it acts as a titrant in iodometry, facilitating analytical procedures.
• References: [1] Sodium thiosulfate in the treatment of calcific uremic arteriolopathy; DOI 10.1038/nrneph.2009.99; [2] Sodium Thiosulfate: New Hope for the Treatment of Calciphylaxis; DOI 10.1111/j.1525-139X.2010.00738.x; [3] Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss; DOI 10.1056/NEJMoa1801109; [4] Sodium thiosulfate: pediatric first approval; DOI 10.1007/s40272-022-00550-x

Refernces

Chlorination and oxidation products formed from 1,2,4-trimethylbenzene in aqueous solution under the action of chlorine dioxide

10.1134/S107042720707018X

The study investigates the reaction products of 1,2,4-trimethylbenzene (1,2,4-TMB) with chlorine dioxide (ClO2) in aqueous solution. The primary purpose of the study is to understand the transformation pathways of 1,2,4-TMB under the influence of ClO2, which is significant in the context of water disinfection and the reduction of secondary toxicants. Chemicals used include 1,2,4-TMB as the organic substrate, ClO2 as the oxidizing agent, sodium chlorite (used to prepare ClO2), hydrochloric acid (reacted with sodium chlorite to produce ClO2), and sodium thiosulfate (to deactivate excess ClO2). The study serves to explore the potential water pollutants' transformation in petrochemical-adjacent regions and to assess the effectiveness of ClO2 as a disinfectant, particularly in reducing the formation of toxic disinfection byproducts.

SYNTHESIS AND BIOLOGICAL ACTIVITY OF DISPIROTRIPIPERAZINIUM DERIVATIVES

10.1007/BF01146185

The research focused on the synthesis and study of dispirotripiperazinium derivatives, which are potential antitumor and radioprotective agents. The purpose was to investigate the biological activity of these compounds, particularly their ability to penetrate the blood-brain barrier due to the presence of a dispirotripiperazinium transport fragment. The study involved the synthesis of various compounds with different hydrocarbon chains and sulfur-containing substituents, including bisthiosulfate, thioacetyl, isothiouronium, and N,N'-bis-(O,O-dimethylthiophosphate) derivatives. The chemicals used in the synthesis process included sodium thiosulfate, lithium thioacetate, thiourea, and chloro-O,O-dimethylthiophosphate, among others. The conclusions drawn from the study were that while these compounds showed varying levels of acute toxicity, likely related to the in vivo release rate of the mercapto group, none of the tested compounds exhibited radioprotective activity. The least toxic substances were found to be the thiosulfate derivatives, whose hydrolysis occurred slowly, while the isothiouronium and acetyl derivatives were more toxic due to their easier hydrolysis.