-O-<<(tert-butyloxy)carbonyl>-S-(acetamidomethyl)-L-cysteinyl-L-valyl>-D-seryl>-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester

Base Information

Chemical Name:-O-<<(tert-butyloxy)carbonyl>-S-(acetamidomethyl)-L-cysteinyl-L-valyl>-D-seryl>-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester
CAS No.:78166-94-6
Molecular Formula:C₃₃H₄₈Cl₃N₅O₁₁S
Molecular Weight:829.196
Hs Code.:

<N-<(Benzyloxy)carbonyl>-O-<<(tert-butyloxy)carbonyl>-S-(acetamidomethyl)-L-cysteinyl-L-valyl>-D-seryl>-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester

Synonyms:-O-<<(tert-butyloxy)carbonyl>-S-(acetamidomethyl)-L-cysteinyl-L-valyl>-D-seryl>-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester

Suppliers and Price of -O-<<(tert-butyloxy)carbonyl>-S-(acetamidomethyl)-L-cysteinyl-L-valyl>-D-seryl>-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of -O-<<(tert-butyloxy)carbonyl>-S-(acetamidomethyl)-L-cysteinyl-L-valyl>-D-seryl>-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of -O-<<(tert-butyloxy)carbonyl>-S-(acetamidomethyl)-L-cysteinyl-L-valyl>-D-seryl>-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester

There total 4 articles about -O-<<(tert-butyloxy)carbonyl>-S-(acetamidomethyl)-L-cysteinyl-L-valyl>-D-seryl>-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 78166-91-3
N-Methyl-L-alanine 2,2,2-Trichloroethyl Ester Hydrobromide

: 78166-94-6
-O-<<(tert-butyloxy)carbonyl>-S-(acetamidomethyl)-L-cysteinyl-L-valyl>-D-seryl>-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / CH₂Cl₂ / 0.08 h / 0 °C

2: 88 percent / Et₃N / CH₂Cl₂ / 60 h / Ambient temperature

3: 87.5 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / 4-(dimethylamino)pyridine / CH₂Cl₂ / 1.) 0 deg C, 3 h, 2.) room temperature, overnight

4: 1.)trifluoroacetic acid, 2.) 1-hydroxybenzotriazole, 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / 1.) 30 min, room temperature, 2.) THF, 1 h, 0 deg C, 3.) 5 h, room temperature

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; dmap; triethylamine; In dichloromethane;
DOI:10.1021/jo00330a010

Reference yield:

: 78166-92-4
-D-seryl>-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester

: 78166-94-6
-O-<<(tert-butyloxy)carbonyl>-S-(acetamidomethyl)-L-cysteinyl-L-valyl>-D-seryl>-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester

Guidance literature:: Multi-step reaction with 2 steps

1: 87.5 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / 4-(dimethylamino)pyridine / CH₂Cl₂ / 1.) 0 deg C, 3 h, 2.) room temperature, overnight

2: 1.)trifluoroacetic acid, 2.) 1-hydroxybenzotriazole, 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / 1.) 30 min, room temperature, 2.) THF, 1 h, 0 deg C, 3.) 5 h, room temperature

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; dmap; In dichloromethane;
DOI:10.1021/jo00330a010

Reference yield:

: 78166-90-2
N-Methyl-L-alanine 2,2,2-Trichloroethyl Ester

: 78166-94-6
-O-<<(tert-butyloxy)carbonyl>-S-(acetamidomethyl)-L-cysteinyl-L-valyl>-D-seryl>-N-methyl-L-alanine 2,2,2-Trichloroethyl Ester

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / Et₃N / CH₂Cl₂ / 60 h / Ambient temperature

2: 87.5 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / 4-(dimethylamino)pyridine / CH₂Cl₂ / 1.) 0 deg C, 3 h, 2.) room temperature, overnight

3: 1.)trifluoroacetic acid, 2.) 1-hydroxybenzotriazole, 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / 1.) 30 min, room temperature, 2.) THF, 1 h, 0 deg C, 3.) 5 h, room temperature

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; dmap; triethylamine; In dichloromethane;
DOI:10.1021/jo00330a010