Technology Process of ethyl (S)-2-(4-chlorophenoxy)-3-[4-[2-[(4-(pyridin-2-yl)benzoyl)amino]ethoxy]phenyl]propionate
There total 6 articles about ethyl (S)-2-(4-chlorophenoxy)-3-[4-[2-[(4-(pyridin-2-yl)benzoyl)amino]ethoxy]phenyl]propionate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 99 percent / K2CO3 / dimethylformamide / 4 h / 60 °C
2: 56 percent / triphenylphosphine; diethyl azodicarboxylate / toluene / 20 °C
3: NaOH / ethanol / 20 °C
4: 99 percent / H2SO4 / 20 °C
5: 78 percent / H2 / Pd/C / ethanol / 50 °C
6: 99 percent / triphenylphosphine; diethyl azodicarboxylate / toluene / 0 - 20 °C
7: HCl / dioxane / 20 °C
8: triethylamine; diethylphosphoryl cyanide / dimethylformamide
With
hydrogenchloride; sodium hydroxide; diethylphosphoryl cyanide; sulfuric acid; hydrogen; potassium carbonate; triethylamine; triphenylphosphine; diethylazodicarboxylate;
palladium on activated charcoal;
In
1,4-dioxane; ethanol; N,N-dimethyl-formamide; toluene;
2: Mitsunobu reaction / 6: Mitsunobu reaction;
DOI:10.1016/j.bmc.2004.01.048
- Guidance literature:
-
Multi-step reaction with 6 steps
1: NaOH / ethanol / 20 °C
2: 99 percent / H2SO4 / 20 °C
3: 78 percent / H2 / Pd/C / ethanol / 50 °C
4: 99 percent / triphenylphosphine; diethyl azodicarboxylate / toluene / 0 - 20 °C
5: HCl / dioxane / 20 °C
6: triethylamine; diethylphosphoryl cyanide / dimethylformamide
With
hydrogenchloride; sodium hydroxide; diethylphosphoryl cyanide; sulfuric acid; hydrogen; triethylamine; triphenylphosphine; diethylazodicarboxylate;
palladium on activated charcoal;
In
1,4-dioxane; ethanol; N,N-dimethyl-formamide; toluene;
4: Mitsunobu reaction;
DOI:10.1016/j.bmc.2004.01.048
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 99 percent / H2SO4 / 20 °C
2: 78 percent / H2 / Pd/C / ethanol / 50 °C
3: 99 percent / triphenylphosphine; diethyl azodicarboxylate / toluene / 0 - 20 °C
4: HCl / dioxane / 20 °C
5: triethylamine; diethylphosphoryl cyanide / dimethylformamide
With
hydrogenchloride; diethylphosphoryl cyanide; sulfuric acid; hydrogen; triethylamine; triphenylphosphine; diethylazodicarboxylate;
palladium on activated charcoal;
In
1,4-dioxane; ethanol; N,N-dimethyl-formamide; toluene;
3: Mitsunobu reaction;
DOI:10.1016/j.bmc.2004.01.048