2-[5-benzyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazol-3-yl]-indole-1,6-dicarboxylic acid 1-tert-butyl ester 6-methyl ester

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Chemical Name:2-[5-benzyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazol-3-yl]-indole-1,6-dicarboxylic acid 1-tert-butyl ester 6-methyl ester
CAS No.:1238062-48-0
Molecular Formula:C₃₀H₃₃N₃O₅
Molecular Weight:515.609
Hs Code.:

Synonyms:2-[5-benzyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazol-3-yl]-indole-1,6-dicarboxylic acid 1-tert-butyl ester 6-methyl ester

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Chemical Property of 2-[5-benzyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazol-3-yl]-indole-1,6-dicarboxylic acid 1-tert-butyl ester 6-methyl ester

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Technology Process of 2-[5-benzyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazol-3-yl]-indole-1,6-dicarboxylic acid 1-tert-butyl ester 6-methyl ester

There total 1 articles about 2-[5-benzyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazol-3-yl]-indole-1,6-dicarboxylic acid 1-tert-butyl ester 6-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 848357-46-0
6-carbocxylic acid methyl ester-1-(tert-butoxycarbonyl)-1H-indol-2-ylboronic acid

: 1238062-46-8
3-benzyl-5-iodo-1-(tetrahydro-pyran-2-yl)-1H-pyrazole

: 1238062-48-0
2-[5-benzyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazol-3-yl]-indole-1,6-dicarboxylic acid 1-tert-butyl ester 6-methyl ester

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; In 1,4-dioxane; at 80 ℃; for 6h; Inert atmosphere;
DOI:10.1016/j.bmc.2010.04.056

Reference yield: 85.0%

: 1238062-48-0
2-[5-benzyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazol-3-yl]-indole-1,6-dicarboxylic acid 1-tert-butyl ester 6-methyl ester

: 1238062-49-1
2-(5-benzyl-1H-pyrazol-3-yl)-1H-indole-6-carboxylic acid methyl ester

Guidance literature:: 2-[5-benzyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazol-3-yl]-indole-1,6-dicarboxylic acid 1-tert-butyl ester 6-methyl ester; With hydrogenchloride; water; In 1,4-dioxane; at 0 ℃;

With potassium carbonate; In methanol; at 20 ℃; for 5h;
DOI:10.1016/j.bmc.2010.04.056