ethyl 4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)phenylphosphonate

Base Information

Chemical Name:ethyl 4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)phenylphosphonate
CAS No.:1428526-25-3
Molecular Formula:C₂₅H₂₃N₄O₅P
Molecular Weight:490.455
Hs Code.:

Synonyms:ethyl 4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)phenylphosphonate

Suppliers and Price of ethyl 4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)phenylphosphonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl 4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)phenylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl 4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)phenylphosphonate

There total 11 articles about ethyl 4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)phenylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1428526-23-1
diethyl 4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)phenylphosphonate

: 1428526-25-3
ethyl 4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)phenylphosphonate

Guidance literature:: diethyl 4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)phenylphosphonate; With sodium hydroxide; In 1,4-dioxane; Reflux;

With trifluoroacetic acid;

Reference yield:

: 90-90-4
(4-bromophenyl)(phenyl)methanone

: 1428526-25-3
ethyl 4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)phenylphosphonate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 24 h / 185 °C

2.1: potassium hydroxide / methanol / 8 h / Reflux

3.1: triethylamine / dichloromethane / 0 °C

3.2: 20 °C

4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / toluene / Reflux

5.1: hydrogenchloride / 1,4-dioxane / 20 °C

6.1: triethylamine; HATU / acetonitrile / 2 h / 20 °C

7.1: sodium hydroxide / 1,4-dioxane / Reflux

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine; HATU; potassium hydroxide; sodium hydroxide; In 1,4-dioxane; methanol; dichloromethane; toluene; acetonitrile;

Reference yield:

: 55095-17-5,220441-81-6
(4-bromophenyl)(phenyl)methanamine

: 1428526-25-3
ethyl 4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)phenylphosphonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 0 °C

1.2: 20 °C

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / toluene / Reflux

3.1: hydrogenchloride / 1,4-dioxane / 20 °C

4.1: triethylamine; HATU / acetonitrile / 2 h / 20 °C

5.1: sodium hydroxide / 1,4-dioxane / Reflux

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine; HATU; sodium hydroxide; In 1,4-dioxane; dichloromethane; toluene; acetonitrile;