N⁽²⁾-[1,1-dimethyl-2-(methylsulfonyl)ethyl]-3-iodo-N⁽¹⁾-[4-(1-hydroxy-1-trifluoromethyl-2,2,2-trifluoroethyl)-2-fluorophenyl]-1,2-benzenedicarboxamide

Base Information

• Chemical Name: N⁽²⁾-[1,1-dimethyl-2-(methylsulfonyl)ethyl]-3-iodo-N⁽¹⁾-[4-(1-hydroxy-1-trifluoromethyl-2,2,2-trifluoroethyl)-2-fluorophenyl]-1,2-benzenedicarboxamide
• CAS No.: 1355338-09-8
• Molecular Formula: C₂₂H₂₀F₇IN₂O₅S
• Molecular Weight: 684.371

Synonyms:N⁽²⁾-[1,1-dimethyl-2-(methylsulfonyl)ethyl]-3-iodo-N⁽¹⁾-[4-(1-hydroxy-1-trifluoromethyl-2,2,2-trifluoroethyl)-2-fluorophenyl]-1,2-benzenedicarboxamide

Chemical Property of N⁽²⁾-[1,1-dimethyl-2-(methylsulfonyl)ethyl]-3-iodo-N⁽¹⁾-[4-(1-hydroxy-1-trifluoromethyl-2,2,2-trifluoroethyl)-2-fluorophenyl]-1,2-benzenedicarboxamide

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Technology Process of N⁽²⁾-[1,1-dimethyl-2-(methylsulfonyl)ethyl]-3-iodo-N⁽¹⁾-[4-(1-hydroxy-1-trifluoromethyl-2,2,2-trifluoroethyl)-2-fluorophenyl]-1,2-benzenedicarboxamide

There total 5 articles about N⁽²⁾-[1,1-dimethyl-2-(methylsulfonyl)ethyl]-3-iodo-N⁽¹⁾-[4-(1-hydroxy-1-trifluoromethyl-2,2,2-trifluoroethyl)-2-fluorophenyl]-1,2-benzenedicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-iodophthalic anhydride (28418-88-4) → N(2)-[1,1-dimethyl-2-(methylsulfonyl)ethyl]-3-iodo-N(1)-[4-(1-hydroxy-1-trifluoromethyl-2,2,2-trifluoroethyl)-2-fluorophenyl]-1,2-benzenedicarboxamide (1355338-09-8)

Guidance literature:

Multi-step reaction with 3 steps

1: acetonitrile

2: trifluoroacetic acid / acetonitrile / 3 h

3: 3-chloro-benzenecarboperoxoic acid / acetonitrile / 3 h / 20 °C

With 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In acetonitrile;

DOI:10.1002/cjoc.201200215

Reference yield:

C22H20F7IN2O3S → N(2)-[1,1-dimethyl-2-(methylsulfonyl)ethyl]-3-iodo-N(1)-[4-(1-hydroxy-1-trifluoromethyl-2,2,2-trifluoroethyl)-2-fluorophenyl]-1,2-benzenedicarboxamide (1355338-09-8)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In acetonitrile; at 20 ℃; for 3h;

DOI:10.1002/cjoc.201200215

Reference yield:

2-Fluoroaniline (348-54-9) → N(2)-[1,1-dimethyl-2-(methylsulfonyl)ethyl]-3-iodo-N(1)-[4-(1-hydroxy-1-trifluoromethyl-2,2,2-trifluoroethyl)-2-fluorophenyl]-1,2-benzenedicarboxamide (1355338-09-8)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / 5,5-dimethyl-1,3-cyclohexadiene / 12 h / 90 - 130 °C

2: trifluoroacetic acid / acetonitrile / 3 h

3: 3-chloro-benzenecarboperoxoic acid / acetonitrile / 3 h / 20 °C

With toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In 5,5-dimethyl-1,3-cyclohexadiene; acetonitrile; 1: Friedel Crafts alkylation;

DOI:10.1002/cjoc.201200215

upstream raw materials:

2-(4-amino-3-fluorophenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

3-iodophthalic anhydride

2-Fluoroaniline

2-methyl-1-methylthio-2-propylamine

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