(2S,3R,4S,5S)-methyl 5-(3-methoxyphenyl)-4-nitro-3-phenylpyrrolidine-2-carboxylate

Base Information

Chemical Name:(2S,3R,4S,5S)-methyl 5-(3-methoxyphenyl)-4-nitro-3-phenylpyrrolidine-2-carboxylate
CAS No.:1223020-35-6
Molecular Formula:C₁₉H₂₀N₂O₅
Molecular Weight:356.378
Hs Code.:

Synonyms:(2S,3R,4S,5S)-methyl 5-(3-methoxyphenyl)-4-nitro-3-phenylpyrrolidine-2-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3R,4S,5S)-methyl 5-(3-methoxyphenyl)-4-nitro-3-phenylpyrrolidine-2-carboxylate

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Technology Process of (2S,3R,4S,5S)-methyl 5-(3-methoxyphenyl)-4-nitro-3-phenylpyrrolidine-2-carboxylate

There total 2 articles about (2S,3R,4S,5S)-methyl 5-(3-methoxyphenyl)-4-nitro-3-phenylpyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 5153-67-3
nitrostyrene

: 868659-08-9
methyl [(3-methoxybenzylidene)amino]acetate

: 1223020-35-6
(2S,3R,4S,5S)-methyl 5-(3-methoxyphenyl)-4-nitro-3-phenylpyrrolidine-2-carboxylate

Guidance literature:: With 2,6-bis((2R,4S,5S)-1-benzyl-4,5-diphenylimidazolidin-2-yl)pyridine; copper(II) bis(trifluoromethanesulfonate); caesium carbonate; In 1,4-dioxane; at 20 ℃; for 22h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ja100265j

Reference yield:

: 868659-08-9
methyl [(3-methoxybenzylidene)amino]acetate

: 102-96-5
(2-nitroethenyl)benzene

: 1223020-35-6
(2S,3R,4S,5S)-methyl 5-(3-methoxyphenyl)-4-nitro-3-phenylpyrrolidine-2-carboxylate

: 1257558-70-5
(2S,3R,4S,5R)-methyl 5-(3-methoxyphenyl)-4-nitro-3-phenylpyrrolidine-2-carboxylate

Guidance literature:: With 2-{[(1S)-N-{[(4S,5S)-4,5-dihydro-4,5-diphenyl-1-tosyl-1H-imidazol-2-yl]methyl}-1-phenylethanamino]methyl}-4,6-dibromophenol; nickel(II) acetate tetrahydrate; potassium carbonate; In acetonitrile; at -10 ℃; for 42h; optical yield given as %ee; stereoselective reaction;
DOI:10.1002/anie.201004098