(R_S,1R)-2-methylpropane-2-sulfinic acid (1-(benzyloxymethyl)propyl)amide

Base Information

• Chemical Name: (R_S,1R)-2-methylpropane-2-sulfinic acid (1-(benzyloxymethyl)propyl)amide
• CAS No.: 393536-24-8
• Molecular Formula: C₁₅H₂₅NO₂S
• Molecular Weight: 283.435
• Mol file: 393536-24-8.mol

Synonyms:(R_S,1R)-2-methylpropane-2-sulfinic acid (1-(benzyloxymethyl)propyl)amide

Chemical Property of (R_S,1R)-2-methylpropane-2-sulfinic acid (1-(benzyloxymethyl)propyl)amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R_S,1R)-2-methylpropane-2-sulfinic acid (1-(benzyloxymethyl)propyl)amide

There total 2 articles about (R_S,1R)-2-methylpropane-2-sulfinic acid (1-(benzyloxymethyl)propyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyloxyacetoaldehyde (60656-87-3) → (RS,1R)-2-methylpropane-2-sulfinic acid (1-(benzyloxymethyl)propyl)amide (393536-24-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / CuSO₄ / CH₂Cl₂ / 24 h / 20 °C

2: toluene / -78 °C

With copper(II) sulfate; In dichloromethane; toluene; 2: Grignard reaction;

DOI:10.1021/jo0156868

Reference yield:

ethylmagnesium bromide (925-90-6) + (R)-N-[(1E)-2-(benzyloxy)ethylidene]-2-methylpropane-2-sulfinamide (393536-17-9) → (RS,1R)-2-methylpropane-2-sulfinic acid (1-(benzyloxymethyl)propyl)amide (393536-24-8) + (RS,1S)-2-methylpropane-2-sulfinic acid (1-(benzyloxymethyl)propyl)amide

Guidance literature:

In toluene; at -78 ℃; Title compound not separated from byproducts.;

DOI:10.1021/jo0156868

Reference yield:

(RS,1R)-2-methylpropane-2-sulfinic acid (1-(benzyloxymethyl)propyl)amide (393536-24-8) → (R)-(-)-2-amino-1-benzyloxy butane (142559-11-3)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 0.5h;

DOI:10.1021/jo0156868

upstream raw materials:

ethylmagnesium bromide

(R)-N-[(1E)-2-(benzyloxy)ethylidene]-2-methylpropane-2-sulfinamide

benzyloxyacetoaldehyde

Downstream raw materials:

(R)-(-)-2-amino-1-benzyloxy butane