(R)-1-(2-(1-(3-benzyloxy-benzenesuylfonyl)-pyrrolidin-2-yl)-ethyl)-4-methyl piperidine

Base Information

Chemical Name:(R)-1-(2-(1-(3-benzyloxy-benzenesuylfonyl)-pyrrolidin-2-yl)-ethyl)-4-methyl piperidine
CAS No.:201038-72-4
Molecular Formula:C₂₅H₃₄N₂O₃S
Molecular Weight:442.623
Hs Code.:

Synonyms:(R)-1-(2-(1-(3-benzyloxy-benzenesuylfonyl)-pyrrolidin-2-yl)-ethyl)-4-methyl piperidine

Suppliers and Price of (R)-1-(2-(1-(3-benzyloxy-benzenesuylfonyl)-pyrrolidin-2-yl)-ethyl)-4-methyl piperidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-1-(2-(1-(3-benzyloxy-benzenesuylfonyl)-pyrrolidin-2-yl)-ethyl)-4-methyl piperidine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (R)-1-(2-(1-(3-benzyloxy-benzenesuylfonyl)-pyrrolidin-2-yl)-ethyl)-4-methyl piperidine

There total 17 articles about (R)-1-(2-(1-(3-benzyloxy-benzenesuylfonyl)-pyrrolidin-2-yl)-ethyl)-4-methyl piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 162711-45-7
3-benzyloxybenzenesulfonyl chloride

: 201039-15-8
(R)-2-[2-(4-methyl-piperidin-1-yl)ethyl]pyrrolidine

: 201038-72-4
(R)-1-(2-(1-(3-benzyloxy-benzenesuylfonyl)-pyrrolidin-2-yl)-ethyl)-4-methyl piperidine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃;
DOI:10.1021/jm991151j

Reference yield:

: 626-58-4
4-methylpiperidin

: 201038-72-4
(R)-1-(2-(1-(3-benzyloxy-benzenesuylfonyl)-pyrrolidin-2-yl)-ethyl)-4-methyl piperidine

Guidance literature:: Multi-step reaction with 3 steps

1: 47 percent / H₂ / PtO₂ / ethanol / 72 h / 35 °C / 2580.26 Torr

2: 100 percent / trifluoroacetic acid / CH₂Cl₂ / 18 h / Heating

3: diisopropylethylamyne / CH₂Cl₂ / 0 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; platinum(IV) oxide; In ethanol; dichloromethane; 1: Catalytic hydrogenation / 2: Acidolysis / 3: Sulfonylation;
DOI:10.1021/jm991151j

Reference yield:

: 68832-13-3
D-prolinol

: 201038-72-4
(R)-1-(2-(1-(3-benzyloxy-benzenesuylfonyl)-pyrrolidin-2-yl)-ethyl)-4-methyl piperidine

Guidance literature:: Multi-step reaction with 6 steps

1: 84 percent / K₂CO₃ / tetrahydrofuran; H₂O / 20 °C / pH 9

2: 100 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

3: 78 percent / dimethylformamide / 6 h / 100 °C

4: 47 percent / H₂ / PtO₂ / ethanol / 72 h / 35 °C / 2580.26 Torr

5: 100 percent / trifluoroacetic acid / CH₂Cl₂ / 18 h / Heating

6: diisopropylethylamyne / CH₂Cl₂ / 0 °C

With hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; platinum(IV) oxide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 1: Acylation / 2: Mesylation / 3: Substitution / 4: Catalytic hydrogenation / 5: Acidolysis / 6: Sulfonylation;
DOI:10.1021/jm991151j