C₂₂H₂₂FNO₆S

Base Information

• Chemical Name: C₂₂H₂₂FNO₆S
• CAS No.: 1374233-43-8
• Molecular Formula: C₂₂H₂₂FNO₆S
• Molecular Weight: 447.484
• Mol file: 1374233-43-8.mol

Synonyms:C₂₂H₂₂FNO₆S

Chemical Property of C₂₂H₂₂FNO₆S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₂₂FNO₆S

There total 8 articles about C₂₂H₂₂FNO₆S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

C20H20FNO6S (1374233-42-7) + (2-bromoethyl)(diphenyl)sulfonium trifluoromethanesulfonate (247129-85-7) → C22H22FNO6S (1374233-43-8)

Guidance literature:

C₂₀H₂₀FNO₆S; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 0.25h; Inert atmosphere;

(2-bromoethyl)(diphenyl)sulfonium trifluoromethanesulfonate; In tetrahydrofuran; mineral oil; at 0 - 20 ℃;

Reference yield:

ethyl 2-(4-fluorophenyl)-5-hydroxy-6-nitrobenzofuran-3-carboxylate (691857-46-2) → C22H22FNO6S (1374233-43-8)

Guidance literature:

Multi-step reaction with 7 steps

1.1: N-ethyl-N,N-diisopropylamine / dmap / dichloromethane / 2 h / 0 °C

2.1: triethylamine / (diphenylphosphin)ferrocene; palladium diacetate / N,N-dimethyl-formamide / 2 h / 100 °C / Inert atmosphere

3.1: hydrogenchloride; water / tetrahydrofuran / 0.25 h / 20 °C

4.1: tin(II) chloride dihdyrate / ethyl acetate / 1 h / 80 °C

4.2: 0.5 h / 20 °C

5.1: pyridine / 1 h / 0 - 20 °C

6.1: sodium tetrahydroborate / ethanol; dichloromethane / 2 h / 0 °C

7.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 - 20 °C / Inert atmosphere

7.2: 0 - 20 °C

With pyridine; hydrogenchloride; sodium tetrahydroborate; tin(II) chloride dihdyrate; water; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; dmap; (diphenylphosphin)ferrocene; palladium diacetate; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; mineral oil;

Reference yield:

ethyl 2-(4-fluorophenyl)-5-isopropoxy-6-nitrobenzofuran-3-carboxylate (691857-07-5) → C22H22FNO6S (1374233-43-8)

Guidance literature:

Multi-step reaction with 8 steps

1.1: boron trichloride / dichloromethane / 1 h / 0 - 20 °C

1.2: Cooling with ice

2.1: N-ethyl-N,N-diisopropylamine / dmap / dichloromethane / 2 h / 0 °C

3.1: triethylamine / (diphenylphosphin)ferrocene; palladium diacetate / N,N-dimethyl-formamide / 2 h / 100 °C / Inert atmosphere

4.1: hydrogenchloride; water / tetrahydrofuran / 0.25 h / 20 °C

5.1: tin(II) chloride dihdyrate / ethyl acetate / 1 h / 80 °C

5.2: 0.5 h / 20 °C

6.1: pyridine / 1 h / 0 - 20 °C

7.1: sodium tetrahydroborate / ethanol; dichloromethane / 2 h / 0 °C

8.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 - 20 °C / Inert atmosphere

8.2: 0 - 20 °C

With pyridine; hydrogenchloride; sodium tetrahydroborate; tin(II) chloride dihdyrate; water; boron trichloride; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; dmap; (diphenylphosphin)ferrocene; palladium diacetate; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

ethyl 2-(4-fluorophenyl)-5-hydroxy-6-nitrobenzofuran-3-carboxylate

ethyl 2-(4-fluorophenyl)-5-isopropoxy-6-nitrobenzofuran-3-carboxylate

ethyl 2-(4-fluorophenyl)-6-nitro-5-(trifluoromethylsulfonyloxy)benzofuran-3-carboxylate

C₂₀H₂₀FNO₆S

Downstream raw materials:

C₂₀H₁₈FNO₆S

C₂₁H₂₁FN₂O₅S

C₂₁H₂₁FN₂O₅S

C₂₁H₂₁FN₂O₅S