((4-methoxyphenyl)carbonyl)-valyl-N-(3-(1,1,1-trifluoro-2-hydroxy-4-methylpentyl))prolinamide

Base Information

Chemical Name:((4-methoxyphenyl)carbonyl)-valyl-N-(3-(1,1,1-trifluoro-2-hydroxy-4-methylpentyl))prolinamide
CAS No.:105080-60-2
Molecular Formula:C24H32 F3 N3 O5
Molecular Weight:499.5231896
Hs Code.:
Mol file:105080-60-2.mol

Synonyms:((4-methoxyphenyl)carbonyl)-valyl-N-(3-(1,1,1-trifluoro-2-hydroxy-4-methylpentyl))prolinamide

Suppliers and Price of ((4-methoxyphenyl)carbonyl)-valyl-N-(3-(1,1,1-trifluoro-2-hydroxy-4-methylpentyl))prolinamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of ((4-methoxyphenyl)carbonyl)-valyl-N-(3-(1,1,1-trifluoro-2-hydroxy-4-methylpentyl))prolinamide

Chemical Property:

Vapor Pressure:4.07E-17mmHg at 25°C
Boiling Point:656.6°Cat760mmHg
Flash Point:350.9°C
PSA：111.79000
Density:1.235g/cm³
LogP:4.18320

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of ((4-methoxyphenyl)carbonyl)-valyl-N-(3-(1,1,1-trifluoro-2-hydroxy-4-methylpentyl))prolinamide

There total 6 articles about ((4-methoxyphenyl)carbonyl)-valyl-N-(3-(1,1,1-trifluoro-2-hydroxy-4-methylpentyl))prolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 105108-37-0
{(S)-2-Methyl-1-[(S)-2-(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propyl}-carbamic acid benzyl ester

: 105080-60-2
{(S)-2-Methyl-1-[(S)-2-((S)-3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propyl}-carbamic acid benzyl ester

Guidance literature:: With dichloro-acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dimethyl sulfoxide; toluene;
DOI:10.1016/S0040-4039(00)74238-9

Reference yield: 70.0%

: 2314-97-8,263005-66-9
iodotrifluoromethane

: 95501-78-3,138811-05-9
(S)-Benzyloxycarbonyl-L-valyl-N-(1-formyl-2-methylpropyl)-L-prolinamide

: 105080-60-2
{(S)-2-Methyl-1-[(S)-2-((S)-3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propyl}-carbamic acid benzyl ester

Guidance literature:: With dichloro-acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; zinc; multistep reaction; stereoselective synthesis; other educt;
DOI:10.1016/S0040-4039(00)74238-9

Reference yield:

: 2026-48-4,473-75-6
(S)-valinol

: 105080-60-2
{(S)-2-Methyl-1-[(S)-2-((S)-3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-pyrrolidine-1-carbonyl]-propyl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: i-BuOCOCl, NMM

2: 1.) Swern 2.) H⁽¹⁺⁾

3: activated zinc / dimethylformamide / 1 h / -20 °C

4: 70 percent / dichloroacetic acid, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylsulfoxide; toluene

With 4-methyl-morpholine; dichloro-acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; zinc; isobutyl chloroformate; In dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4039(00)74238-9