Chemical Property of LAVENDUSTIN A
Chemical Property:
- Appearance/Colour:Off-White Solid
- Vapor Pressure:4.23E-23mmHg at 25°C
- Melting Point:205-215℃
- Boiling Point:741.7°C at 760 mmHg
- PKA:2.31±0.10(Predicted)
- Flash Point:402.4°C
- PSA：121.46000
- Density:1.495±0.06 g/cm3(Predicted)
- LogP:3.41400
- Storage Temp.:−20°C
- Sensitive.:Air Sensitive
- Solubility.:DMSO: soluble
- XLogP3:3.7
- Hydrogen Bond Donor Count:5
- Hydrogen Bond Acceptor Count:7
- Rotatable Bond Count:6
- Exact Mass:381.12123733
- Heavy Atom Count:28
- Complexity:517
- Purity/Quality:
-
99%, *data from raw suppliers
Lavendustin A *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi
- Hazard Codes:Xi
- Statements:
36/37/38
- Safety Statements:
37/39-26
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1=CC=C(C(=C1)CN(CC2=C(C=CC(=C2)O)O)C3=CC(=C(C=C3)O)C(=O)O)O
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Description
Lavendustin A is a selective inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase (IC50 = 11 nM) that was first isolated from a Streptomyces culture filtrate. It does not inhibit protein kinase A (PKA), PKC, or PI3K (IC50s > 100 μM). It has been used to differentiate rat mesenchymal stem cells, to inhibit NMDA-stimulated cGMP production, and to inhibit VEGF-induced angiogenesis.
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Uses
A potent tyrosine kinase inhibitor. Inhibition is competitive with ATP and is noncompetitive with the peptide A potent tyrosine kinase inhibitor. Inhibition is competitive with ATP and is noncompetitive with the peptide.
