2-Methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acetonitrile

Base Information

Chemical Name:2-Methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acetonitrile
CAS No.:76081-98-6
Molecular Formula:C17H15 N3 O
Molecular Weight:277.326
Hs Code.:2933990090
UNII:00427X161I
DSSTox Substance ID:DTXSID10226971
Nikkaji Number:J23.600D
Wikidata:Q27164711
Pharos Ligand ID:78W9RJ8D6WUM
ChEMBL ID:CHEMBL47529
Mol file:76081-98-6.mol

Synonyms:2-methyl-8-(phenylmethoxy)imidazo-(1-2-a)pyrine-3-acetonitrile;S28080;Sch 28080;Sch-28080;Sch28080;Schering compound 28080

Suppliers and Price of 2-Methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acetonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
SCH 28080
10mg
$ 466.00

Usbiological
SCH 28080
10mg
$ 502.00

TRC
SCH28080
100mg
$ 1175.00

Tocris
SCH28080 ≥99%(HPLC)
10
$ 182.00

Tocris
SCH28080 ≥99%(HPLC)
50
$ 738.00

Sigma-Aldrich
SCH-28080 ≥98% (HPLC), solid
50mg
$ 788.00

Sigma-Aldrich
SCH-28080 ≥98% (HPLC), solid
10mg
$ 186.00

ChemScene
SCH28080 ≥99.0%
1mg
$ 60.00

Cayman Chemical
SCH 28080 ≥98%
50mg
$ 676.00

Cayman Chemical
SCH 28080 ≥98%
1mg
$ 28.00

Total 9 raw suppliers

Chemical Property of 2-Methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acetonitrile

Chemical Property:

PKA:5.85±0.10(Predicted)
PSA：50.32000
Density:1.16g/cm³
LogP:3.28778
Storage Temp.:−20°C
Solubility.:DMSO: >10 mg/mL, soluble
XLogP3:3.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:277.121512110
Heavy Atom Count:21
Complexity:385

Purity/Quality:

99%, ^*data from raw suppliers

SCH 28080 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: 22-24/25

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(N2C=CC=C(C2=N1)OCC3=CC=CC=C3)CC#N
Description SCH 28080 is a reversible K+-competitive inhibitor of H+/K+-ATPases that is best known for its ability to block acid secretion through its action against the gastric H+/K+-ATPase (IC50 = 1.3 μM). It is effective against gastric H+/K+-ATPases from a variety of species and can inhibit colonic H+/K+-ATPases, but this activity appears to be species-dependent. SCH 28080 is also used to investigate the role of H+/K+-ATPases in non-mammalian organisms and to distinguish the actions of H+/K+-ATPases from other ATP-dependent transporters.
Uses SCH 28080 is a potent inhibitor of H+,K+-ATPase.

Technology Process of 2-Methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acetonitrile

There total 6 articles about 2-Methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%