(2R,3S)-syn-3-diphenylphosphinylamino-2-(9H-fluoren-9-ylidene)amino-3-phenylpropanenitrile

Base Information

Chemical Name:(2R,3S)-syn-3-diphenylphosphinylamino-2-(9H-fluoren-9-ylidene)amino-3-phenylpropanenitrile
CAS No.:1393342-31-8
Molecular Formula:C₃₄H₂₆N₃OP
Molecular Weight:523.574
Hs Code.:

Synonyms:(2R,3S)-syn-3-diphenylphosphinylamino-2-(9H-fluoren-9-ylidene)amino-3-phenylpropanenitrile

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Chemical Property of (2R,3S)-syn-3-diphenylphosphinylamino-2-(9H-fluoren-9-ylidene)amino-3-phenylpropanenitrile

Chemical Property:

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Technology Process of (2R,3S)-syn-3-diphenylphosphinylamino-2-(9H-fluoren-9-ylidene)amino-3-phenylpropanenitrile

There total 3 articles about (2R,3S)-syn-3-diphenylphosphinylamino-2-(9H-fluoren-9-ylidene)amino-3-phenylpropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1334168-04-5
N-(9-fluorenylidene) α-aminoacetonitrile

: 98837-46-8,67764-52-7
P,P-diphenyl-N-(phenylmethylene)phosphinic amide

: (2S,3R)-syn-3-diphenylphosphinylamino-2-(9H-fluoren-9-ylidene)amino-3-phenylpropanenitrile

: 1393342-31-8
(2R,3S)-syn-3-diphenylphosphinylamino-2-(9H-fluoren-9-ylidene)amino-3-phenylpropanenitrile

: 1334168-05-6
anti-3-diphenylphosphinylamino-2-(9H-fluoren-9-ylidene)amino-3-phenylpropanenitrile

Guidance literature:: With C₂₃H₃₀N₂O; In diethyl ether; dichloromethane; at 25 ℃; for 0.5h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2012.06.044

Reference yield:

: 486-25-9,952573-42-1
9-fluorenone

: (2S,3R)-syn-3-diphenylphosphinylamino-2-(9H-fluoren-9-ylidene)amino-3-phenylpropanenitrile

: 1393342-31-8
(2R,3S)-syn-3-diphenylphosphinylamino-2-(9H-fluoren-9-ylidene)amino-3-phenylpropanenitrile

: 1334168-05-6
anti-3-diphenylphosphinylamino-2-(9H-fluoren-9-ylidene)amino-3-phenylpropanenitrile

Guidance literature:: Multi-step reaction with 3 steps

1: ammonia; titanium tetrachloride / toluene

2: dichloromethane / 20 °C

3: C₂₃H₃₀N₂O / diethyl ether; dichloromethane / 0.5 h / 25 °C / Inert atmosphere

With C₂₃H₃₀N₂O; ammonia; titanium tetrachloride; In diethyl ether; dichloromethane; toluene; 3: Mannich type reaction;
DOI:10.1016/j.tet.2012.06.044

Reference yield:

: 4440-33-9
fluorenone imine

: (2S,3R)-syn-3-diphenylphosphinylamino-2-(9H-fluoren-9-ylidene)amino-3-phenylpropanenitrile

: 1393342-31-8
(2R,3S)-syn-3-diphenylphosphinylamino-2-(9H-fluoren-9-ylidene)amino-3-phenylpropanenitrile

: 1334168-05-6
anti-3-diphenylphosphinylamino-2-(9H-fluoren-9-ylidene)amino-3-phenylpropanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 20 °C

2: C₂₃H₃₀N₂O / diethyl ether; dichloromethane / 0.5 h / 25 °C / Inert atmosphere

With C₂₃H₃₀N₂O; In diethyl ether; dichloromethane; 2: Mannich type reaction;
DOI:10.1016/j.tet.2012.06.044