(±)-4-((3,5-bis(trifluoromethyl)benzyloxy)methyl)-4-phenylazepane

Base Information

Chemical Name:(±)-4-((3,5-bis(trifluoromethyl)benzyloxy)methyl)-4-phenylazepane
CAS No.:1440958-47-3
Molecular Formula:C₂₂H₂₃F₆NO
Molecular Weight:431.421
Hs Code.:

Synonyms:(±)-4-((3,5-bis(trifluoromethyl)benzyloxy)methyl)-4-phenylazepane

Suppliers and Price of (±)-4-((3,5-bis(trifluoromethyl)benzyloxy)methyl)-4-phenylazepane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (±)-4-((3,5-bis(trifluoromethyl)benzyloxy)methyl)-4-phenylazepane

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Technology Process of (±)-4-((3,5-bis(trifluoromethyl)benzyloxy)methyl)-4-phenylazepane

There total 7 articles about (±)-4-((3,5-bis(trifluoromethyl)benzyloxy)methyl)-4-phenylazepane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1429045-55-5
C₂₂H₂₁F₆NO₂

: 1440958-47-3
(±)-4-((3,5-bis(trifluoromethyl)benzyloxy)methyl)-4-phenylazepane

Guidance literature:: C₂₂H₂₁F₆NO₂; With borane-THF; at 20 - 65 ℃;

With hydrogenchloride; In methanol; water; at 65 ℃; for 2h;
DOI:10.1016/j.bmc.2013.02.010

Reference yield:

: 25115-74-6
4-cyano-4-phenylcyclohexanone

: 1440958-47-3
(±)-4-((3,5-bis(trifluoromethyl)benzyloxy)methyl)-4-phenylazepane

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridinium p-toluenesulfonate / benzene / 111 °C / Dean-Stark

2.1: diisobutylaluminium hydride / toluene / 2 h / -78 °C

3.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 1 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 0 - 20 °C

5.1: hydrogenchloride / water; acetone / 1 h / Reflux

6.1: sodium azide; trifluoroacetic acid / water; benzene / 1 h / 65 °C

7.1: borane-THF / 20 - 65 °C

7.2: 2 h / 65 °C

With hydrogenchloride; sodium tetrahydroborate; sodium azide; borane-THF; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; trifluoroacetic acid; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetone; toluene; mineral oil; benzene; 6.1: |Schmidt Reaction;
DOI:10.1016/j.bmc.2013.02.010

Reference yield:

: 56327-24-3
8-phenyl-1,4-dioxaspiro[4,5]decane-8-carboxaldehyde

: 1440958-47-3
(±)-4-((3,5-bis(trifluoromethyl)benzyloxy)methyl)-4-phenylazepane

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 1 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 0 - 20 °C

3.1: hydrogenchloride / water; acetone / 1 h / Reflux

4.1: sodium azide; trifluoroacetic acid / water; benzene / 1 h / 65 °C

5.1: borane-THF / 20 - 65 °C

5.2: 2 h / 65 °C

With hydrogenchloride; sodium tetrahydroborate; sodium azide; borane-THF; sodium hydride; trifluoroacetic acid; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetone; mineral oil; benzene; 4.1: |Schmidt Reaction;
DOI:10.1016/j.bmc.2013.02.010