(Z)-tetrahydro-2H-pyran-4-yl 3-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)acrylate

Base Information

Chemical Name:(Z)-tetrahydro-2H-pyran-4-yl 3-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)acrylate
CAS No.:1333151-90-8
Molecular Formula:C₁₆H₁₆ClN₃O₃
Molecular Weight:333.774
Hs Code.:

Synonyms:(Z)-tetrahydro-2H-pyran-4-yl 3-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)acrylate

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Chemical Property of (Z)-tetrahydro-2H-pyran-4-yl 3-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)acrylate

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Technology Process of (Z)-tetrahydro-2H-pyran-4-yl 3-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)acrylate

There total 7 articles about (Z)-tetrahydro-2H-pyran-4-yl 3-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 2.47%

: 2081-44-9
Tetrahydro-pyran-4-ol

: 1333152-88-7
(Z)-3-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)acrylic acid

: 1333151-90-8
(Z)-tetrahydro-2H-pyran-4-yl 3-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)acrylate

Guidance literature:: sulfuric acid; In tetrahydrofuran; Reflux;

Reference yield:

: 766-84-7
3-chloro-benzonitrile

: 1333151-90-8
(Z)-tetrahydro-2H-pyran-4-yl 3-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)acrylate

Guidance literature:: Multi-step reaction with 6 steps

1: magnesium(II) chloride hexahydrate; sodium monohydrogen sulfide x-hydrate / N,N-dimethyl-formamide / 2 h / 20 °C

2: diethyl ether / 24 h

3: N,N-dimethyl-formamide / 90 °C / Inert atmosphere

4: triethylamine / acetonitrile / 90 °C / Inert atmosphere; Cooling

5: water; lithium hydroxide / tetrahydrofuran / 20 °C

6: sulfuric acid / tetrahydrofuran / Reflux

With sodium monohydrogen sulfide x-hydrate; magnesium(II) chloride hexahydrate; water; triethylamine; lithium hydroxide; sulfuric acid; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 2548-79-0
3-chlorothiobenzamide

: 1333151-90-8
(Z)-tetrahydro-2H-pyran-4-yl 3-(3-(3-chlorophenyl)-1H-1,2,4-triazol-1-yl)acrylate

Guidance literature:: Multi-step reaction with 5 steps

1: diethyl ether / 24 h

2: N,N-dimethyl-formamide / 90 °C / Inert atmosphere

3: triethylamine / acetonitrile / 90 °C / Inert atmosphere; Cooling

4: water; lithium hydroxide / tetrahydrofuran / 20 °C

5: sulfuric acid / tetrahydrofuran / Reflux

With water; triethylamine; lithium hydroxide; sulfuric acid; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; acetonitrile;