C₁₆H₁₈SiC₈H₁₂O₂CH₂OC₁₇H₂₂O

Base Information

• Chemical Name: C₁₆H₁₈SiC₈H₁₂O₂CH₂OC₁₇H₂₂O
• CAS No.: 954145-09-6
• Molecular Formula: C₄₂H₅₄O₄Si
• Molecular Weight: 650.974
• Mol file: 954145-09-6.mol

Synonyms:C₁₆H₁₈SiC₈H₁₂O₂CH₂OC₁₇H₂₂O

Chemical Property of C₁₆H₁₈SiC₈H₁₂O₂CH₂OC₁₇H₂₂O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of C₁₆H₁₈SiC₈H₁₂O₂CH₂OC₁₇H₂₂O

There total 9 articles about C₁₆H₁₈SiC₈H₁₂O₂CH₂OC₁₇H₂₂O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C16H18SiC8H12O2CH2O (954145-02-9) + (1S,2R)-dimethoxyphosphanyl-2-(2-phenylpropan-2-yl)cyclohexyl 2-(dimethoxyphosphoryl)acetate (200432-33-3) → C16H18SiC8H12O2CH2OC17H22O (954145-09-6) + C16H18SiC8H12O2CH2OC17H22O

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -78 - -20 ℃; for 29h;

DOI:10.1021/ol701783z

Reference yield:

C16H18SiC8H12O2CH2H2O (954145-08-5) → C16H18SiC8H12O2CH2OC17H22O (954145-09-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / DMSO; oxalyl chloride; triethylamine / CH₂Cl₂ / -78 - 20 °C

2: n-BuLi / tetrahydrofuran; hexane / 29 h / -78 - -20 °C

With n-butyllithium; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; hexane; dichloromethane; 1: Swern oxidation / 2: Horner-Emmons olefination;

DOI:10.1021/ol701783z

Reference yield:

C10H14O3O (154635-30-0) → C16H18SiC8H12O2CH2OC17H22O (954145-09-6)

Guidance literature:

Multi-step reaction with 8 steps

1.1: 88 percent / K₂CO₃ / methanol; H₂O / 20 h / 20 °C

2.1: 100 percent / imidazole / dimethylformamide / 36 h / 20 °C

3.1: tetrahydrofuran; toluene / 3 h / 90 °C

4.1: 9-borabicyclo[3.3.1]nonane / tetrahydrofuran / 1 h / 0 - 20 °C

4.2: 766.8 mg / NaOH; H₂O₂ / tetrahydrofuran; H₂O / 0 - 20 °C

5.1: 98 percent / imidazole / dimethylformamide / 3 h / 20 °C

6.1: 93 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / tetrahydrofuran; H₂O / 36 h / 20 °C

7.1: 96 percent / DMSO; oxalyl chloride; triethylamine / CH₂Cl₂ / -78 - 20 °C

8.1: n-BuLi / tetrahydrofuran; hexane / 29 h / -78 - -20 °C

With 1H-imidazole; n-butyllithium; oxalyl dichloride; potassium carbonate; dimethyl sulfoxide; triethylamine; 9-bora-bicyclo[3.3.1]nonane; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene; 3.1: Petasis olefination / 7.1: Swern oxidation / 8.1: Horner-Emmons olefination;

DOI:10.1021/ol701783z

upstream raw materials:

C₁₆H₁₈SiC₈H₁₂O₂CH₂O

(1S,2R)-dimethoxyphosphanyl-2-(2-phenylpropan-2-yl)cyclohexyl 2-(dimethoxyphosphoryl)acetate

C₁₆H₁₈SiC₈H₁₂O₂CH₂H₂O

C₁₀H₁₄O₃

Downstream raw materials:

C₂H₄C₁₆H₁₈SiC₈H₁₂O₂CH₂O