6-(4-hydroxy-phenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid piperidin-4-ylamide hydrochloride salt

Base Information

Chemical Name:6-(4-hydroxy-phenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid piperidin-4-ylamide hydrochloride salt
CAS No.:1431977-13-7
Molecular Formula:C₁₈H₁₉N₅O₂*ClH
Molecular Weight:373.842
Hs Code.:

Synonyms:6-(4-hydroxy-phenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid piperidin-4-ylamide hydrochloride salt

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Chemical Property of 6-(4-hydroxy-phenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid piperidin-4-ylamide hydrochloride salt

Chemical Property:

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Technology Process of 6-(4-hydroxy-phenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid piperidin-4-ylamide hydrochloride salt

There total 8 articles about 6-(4-hydroxy-phenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid piperidin-4-ylamide hydrochloride salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1431978-16-3
6-(4-hydroxy-phenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid(1-Boc-piperidin-4-yl)-amide

: 1431977-13-7
6-(4-hydroxy-phenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid piperidin-4-ylamide hydrochloride salt

Guidance literature:: With hydrogenchloride; In isopropyl alcohol;

Reference yield:

: 1431978-08-3
1-(4-methoxy-benzyl)-6-trifluoromethanesulfonyloxy-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid methyl ester

: 1431977-13-7
6-(4-hydroxy-phenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid piperidin-4-ylamide hydrochloride salt

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran; water / 4 h / 70 °C

1.2: 70 °C

2.1: trifluoroacetic acid / 0.33 h / 20 - 120 °C / Microwave irradiation

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

4.1: hydrogenchloride / isopropyl alcohol

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; water; N,N-dimethyl-formamide; isopropyl alcohol; 1.1: |Suzuki Coupling;

Reference yield:

: 1431978-09-4
6-(4-hydroxy-phenyl)-1-(4-methoxy-benzyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

: 1431977-13-7
6-(4-hydroxy-phenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid piperidin-4-ylamide hydrochloride salt

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / 0.33 h / 20 - 120 °C / Microwave irradiation

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

3: hydrogenchloride / isopropyl alcohol

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In N,N-dimethyl-formamide; isopropyl alcohol;