2-methoxy-benzene-1,3,5-tricarboxylic acid 5-amide 1,3-bis-[(5-amino-2,4-dibutoxy-phenyl)-amide]

Base Information

Chemical Name:2-methoxy-benzene-1,3,5-tricarboxylic acid 5-amide 1,3-bis-[(5-amino-2,4-dibutoxy-phenyl)-amide]
CAS No.:911282-05-8
Molecular Formula:C₃₈H₅₃N₅O₈
Molecular Weight:707.868
Hs Code.:

Synonyms:2-methoxy-benzene-1,3,5-tricarboxylic acid 5-amide 1,3-bis-[(5-amino-2,4-dibutoxy-phenyl)-amide]

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Chemical Property of 2-methoxy-benzene-1,3,5-tricarboxylic acid 5-amide 1,3-bis-[(5-amino-2,4-dibutoxy-phenyl)-amide]

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Technology Process of 2-methoxy-benzene-1,3,5-tricarboxylic acid 5-amide 1,3-bis-[(5-amino-2,4-dibutoxy-phenyl)-amide]

There total 5 articles about 2-methoxy-benzene-1,3,5-tricarboxylic acid 5-amide 1,3-bis-[(5-amino-2,4-dibutoxy-phenyl)-amide] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 911282-04-7
5-carbamoyl-2-methoxy-isophthalic acid

: 4,6-dibutoxy-benzene-1,3-diamine

: 911282-05-8
2-methoxy-benzene-1,3,5-tricarboxylic acid 5-amide 1,3-bis-[(5-amino-2,4-dibutoxy-phenyl)-amide]

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 8h;
DOI:10.1021/ja064218i

Reference yield:

: 201416-10-6
dimethyl 2-methoxy-5-methylisophthalate

: 911282-05-8
2-methoxy-benzene-1,3,5-tricarboxylic acid 5-amide 1,3-bis-[(5-amino-2,4-dibutoxy-phenyl)-amide]

Guidance literature:: Multi-step reaction with 5 steps

1: 60 percent / chromium trioxide / H₂O; acetic acid / 24 h / Heating

2: oxalyl chloride / benzene; dimethylformamide / 2 h / 20 °C

3: 0.75 g / aq. ammonia / tetrahydrofuran / 2 h / 20 °C

4: 90 percent / aq. sodium hydroxide / tetrahydrofuran / 2 h / 20 °C

5: 30 percent / BOP; DIEA / dimethylformamide / 8 h / 20 °C

With chromium(VI) oxide; ammonium hydroxide; sodium hydroxide; oxalyl dichloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; acetic acid; N,N-dimethyl-formamide; benzene;
DOI:10.1021/ja064218i

Reference yield:

: 911282-02-5
2-methoxy-benzene-1,3,5-tricarboxylic acid 1,3-dimethyl ester

: 911282-05-8
2-methoxy-benzene-1,3,5-tricarboxylic acid 5-amide 1,3-bis-[(5-amino-2,4-dibutoxy-phenyl)-amide]

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl chloride / benzene; dimethylformamide / 2 h / 20 °C

2: 0.75 g / aq. ammonia / tetrahydrofuran / 2 h / 20 °C

3: 90 percent / aq. sodium hydroxide / tetrahydrofuran / 2 h / 20 °C

4: 30 percent / BOP; DIEA / dimethylformamide / 8 h / 20 °C

With ammonium hydroxide; sodium hydroxide; oxalyl dichloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; benzene;
DOI:10.1021/ja064218i