C₂₆H₂₂N₈O

Base Information

• Chemical Name: C₂₆H₂₂N₈O
• CAS No.: 1350643-52-5
• Molecular Formula: C₂₆H₂₂N₈O
• Molecular Weight: 462.514
• Mol file: 1350643-52-5.mol

Synonyms:C₂₆H₂₂N₈O

Chemical Property of C₂₆H₂₂N₈O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₆H₂₂N₈O

There total 5 articles about C₂₆H₂₂N₈O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

(S)-3-(1-aminoethyl)-8-(1-methyl-1H-pyrazol-4-yl)-2-phenylisoquinolin-1(2H)-one (1350643-65-0) + 4-amino-6-chloropyrimidine-5-carbonitrile (60025-09-4) → C26H22N8O (1350643-52-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In butan-1-ol; at 120 ℃; for 72h;

Reference yield:

aniline (62-53-3) → C26H22N8O (1350643-52-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

1.2: 2 h / 20 - 40 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -30 - -10 °C / Inert atmosphere

2.2: 1 h / -30 - -10 °C / Inert atmosphere

2.3: 1 h / Reflux

3.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl amine; water / 3 h / 120 °C / in a sealed tube

4.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 72 h / 120 °C

With n-butyllithium; oxalyl dichloride; sodium carbonate; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; N,N-dimethyl-formamide; In tetrahydrofuran; hexane; dichloromethane; water; dimethyl amine; butan-1-ol;

Reference yield:

2-chloro-6-methylbenzoic acid (21327-86-6) → C26H22N8O (1350643-52-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

1.2: 2 h / 20 - 40 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -30 - -10 °C / Inert atmosphere

2.2: 1 h / -30 - -10 °C / Inert atmosphere

2.3: 1 h / Reflux

3.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl amine; water / 3 h / 120 °C / in a sealed tube

4.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 72 h / 120 °C

With n-butyllithium; oxalyl dichloride; sodium carbonate; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; N,N-dimethyl-formamide; In tetrahydrofuran; hexane; dichloromethane; water; dimethyl amine; butan-1-ol;

upstream raw materials:

aniline

2-chloro-6-methylbenzoic acid

(S)-3-(1-aminoethyl)-8-(1-methyl-1H-pyrazol-4-yl)-2-phenylisoquinolin-1(2H)-one

4-amino-6-chloropyrimidine-5-carbonitrile