C₄₈H₇₇IO₈Si₂

Base Information

Chemical Name:C₄₈H₇₇IO₈Si₂
CAS No.:814919-94-3
Molecular Formula:C₄₈H₇₇IO₈Si₂
Molecular Weight:965.21
Hs Code.:

C<sub>48</sub>H<sub>77</sub>IO<sub>8</sub>Si<sub>2</sub>

Synonyms:C₄₈H₇₇IO₈Si₂

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Chemical Property of C₄₈H₇₇IO₈Si₂

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Technology Process of C₄₈H₇₇IO₈Si₂

There total 36 articles about C₄₈H₇₇IO₈Si₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 814919-93-2
C₄₈H₇₅IO₈Si₂

: 814919-94-3
C₄₈H₇₇IO₈Si₂

: 814920-28-0
C₄₈H₇₇IO₈Si₂

Guidance literature:: With diisobutylaluminium hydride; In hexane; dichloromethane; at -78 ℃; for 0.25h;
DOI:10.1021/jo048681u

Reference yield:

: 312923-90-3
(1S,3R,7R,8S,9R,10S,11S)-9-Benzyloxymethyl-10-hydroxymethyl-11-methyl-7-trimethylsilanyloxy-4-oxa-tricyclo[5.3.1.0^3,8]undecan-5-one

: 814919-94-3
C₄₈H₇₇IO₈Si₂

Guidance literature:: Multi-step reaction with 33 steps

1.1: 29 percent / diacetoxyiodobenzene; iodine / CH₂Cl₂ / 0.83 h / 0 °C / Irradiation

2.1: 86 percent / i-Pr₂NEt / CH₂Cl₂ / 10 h / 20 °C

3.1: O₃ / CH₂Cl₂ / 0.25 h / -78 °C

3.2: 83 percent / PPh₃ / CH₂Cl₂ / -78 - 20 °C

4.1: Zn(BH₄)2 / diethyl ether / 0.5 h / 0 °C

5.1: tetrabutylammonium fluoride / tetrahydrofuran / 0.17 h / 0 °C

6.1: 2.25 g / PPTS / acetone / 14 h / 20 °C

7.1: LiHMDS; HMPA / tetrahydrofuran / 1.5 h / -78 °C

7.2: 86 percent / tetrahydrofuran / 0.92 h / -78 - -40 °C

8.1: O₃ / CH₂Cl₂ / 0.08 h / -78 °C

8.2: triphenylphosphine / CH₂Cl₂ / -78 - 20 °C

9.1: 197 mg / NaBH₄ / CH₂Cl₂; methanol / 0.08 h / 20 °C

10.1: 97 percent / n-Bu₃P / tetrahydrofuran / 1.67 h / -78 - 20 °C

11.1: 252 mg / H₂O₂ / tetrahydrofuran / 12 h / 20 °C

12.1: 335 mg / LiAlH₄ / dioxane / 0.02 h / Heating

13.1: 345 mg / Et₃N; DMAP / CH₂Cl₂ / 1.17 h / 20 °C

14.1: 93 percent / 4-methylmorpholine N-oxide / TPAP / acetonitrile / 1 h / 20 °C

15.1: O₃ / CH₂Cl₂ / 0.67 h / -78 °C

15.2: 88 percent / triphenylphosphine / CH₂Cl₂ / -78 - 20 °C

16.1: 86 percent / SmI₂; HMPA / tetrahydrofuran / 0.75 h / -40 - 0 °C

17.1: 87 percent / DMAP / tetrahydrofuran / 6 h / 20 °C

18.1: 96 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.67 h / 20 °C

19.1: 98 percent / Dess-Martin periodinane / CH₂Cl₂ / 0.58 h / 20 °C

20.1: 90 percent / NaBH₄; CeCl₃*7H₂O / methanol / 0.25 h / 0 °C

21.1: 77 percent / zinc chloride / CH₂Cl₂ / 0.75 h

22.1: 45 percent / (TMS)3SiH; AIBN / benzene / 0.33 h / Heating

23.1: 91 percent / cesium fluoride / dimethylformamide / 46 h / 130 °C

24.1: 91 percent / Dess-Martin periodinane / CH₂Cl₂ / 0.92 h / 20 °C

25.1: n-BuLi / tetrahydrofuran; hexane / 0.42 h / 20 °C

25.2: 92 percent / tetrahydrofuran; hexane / 0 - 20 °C

26.1: dicyclohexylborane / tetrahydrofuran / 0.33 h / 0 °C

26.2: 92 percent / H₂O₂; NaOH / tetrahydrofuran / 0 - 20 °C

27.1: 93 percent / i-Pr₂NEt / CH₂Cl₂ / 0 - 20 °C

28.1: 98 percent / hydrogen / Pd(OH)2 on carbon / ethyl acetate / 0.5 h / 20 °C

29.1: 91 percent / Dess-Martin periodinane / CH₂Cl₂ / 1.08 h / 20 °C

30.1: tetrahydrofuran; hexane / 0 - 20 °C

30.2: 94 percent / t-BuOK / tetrahydrofuran / 1.08 h

31.1: 95 percent / hydrogen / Pd on carbon / ethyl acetate / 42 h / 20 °C

32.1: 88 percent / iodobenzene diacetate; iodine / CH₂Cl₂ / 1.75 h / 0 °C / Irradiation

33.1: 73 percent / DIBAL / CH₂Cl₂; hexane / 0.25 h / -78 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; sodium tetrahydroborate; lithium aluminium tetrahydride; n-butyllithium; samarium diiodide; cerium(III) chloride; zinc(II) tetrahydroborate; 2,2'-azobis(isobutyronitrile); tributylphosphine; [bis(acetoxy)iodo]benzene; tris-(trimethylsilyl)silane; bis(cyclohexanyl)borane; tetrabutyl ammonium fluoride; hydrogen; dihydrogen peroxide; iodine; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; Dess-Martin periodane; ozone; 4-methylmorpholine N-oxide; triethylamine; N-ethyl-N,N-diisopropylamine; cesium fluoride; zinc(II) chloride; lithium hexamethyldisilazane; palladium on activated charcoal; tetrapropylammonium perruthennate; palladium hydroxide - carbon; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetone; acetonitrile; benzene; 11.1: Grieco olefination / 19.1: Dess-Martin oxidation / 24.1: Dess-Martin oxidation / 25.2: Wittig reaction / 29.1: Dess-Martin oxidation / 30.1: Wittig reaction;
DOI:10.1021/jo048681u

Reference yield:

: 814920-12-2
C₂₇H₃₆O₇

: 814919-94-3
C₄₈H₇₇IO₈Si₂

Guidance literature:: Multi-step reaction with 9 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.42 h / 20 °C

1.2: 92 percent / tetrahydrofuran; hexane / 0 - 20 °C

2.1: dicyclohexylborane / tetrahydrofuran / 0.33 h / 0 °C

2.2: 92 percent / H₂O₂; NaOH / tetrahydrofuran / 0 - 20 °C

3.1: 93 percent / i-Pr₂NEt / CH₂Cl₂ / 0 - 20 °C

4.1: 98 percent / hydrogen / Pd(OH)2 on carbon / ethyl acetate / 0.5 h / 20 °C

5.1: 91 percent / Dess-Martin periodinane / CH₂Cl₂ / 1.08 h / 20 °C

6.1: tetrahydrofuran; hexane / 0 - 20 °C

6.2: 94 percent / t-BuOK / tetrahydrofuran / 1.08 h

7.1: 95 percent / hydrogen / Pd on carbon / ethyl acetate / 42 h / 20 °C

8.1: 88 percent / iodobenzene diacetate; iodine / CH₂Cl₂ / 1.75 h / 0 °C / Irradiation

9.1: 73 percent / DIBAL / CH₂Cl₂; hexane / 0.25 h / -78 °C

With n-butyllithium; [bis(acetoxy)iodo]benzene; bis(cyclohexanyl)borane; hydrogen; iodine; diisobutylaluminium hydride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; palladium hydroxide - carbon; In tetrahydrofuran; hexane; dichloromethane; ethyl acetate; 1.2: Wittig reaction / 5.1: Dess-Martin oxidation / 6.1: Wittig reaction;
DOI:10.1021/jo048681u