[6-(2-pyridin-2-yl-ethyl)-pyridin-2-yl]-di-p-tolyl-methanol

Base Information

• Chemical Name: [6-(2-pyridin-2-yl-ethyl)-pyridin-2-yl]-di-p-tolyl-methanol
• CAS No.: 539836-41-4
• Molecular Formula: C₂₇H₂₆N₂O
• Molecular Weight: 394.516
• Mol file: 539836-41-4.mol

Synonyms:[6-(2-pyridin-2-yl-ethyl)-pyridin-2-yl]-di-p-tolyl-methanol

Chemical Property of [6-(2-pyridin-2-yl-ethyl)-pyridin-2-yl]-di-p-tolyl-methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [6-(2-pyridin-2-yl-ethyl)-pyridin-2-yl]-di-p-tolyl-methanol

There total 11 articles about [6-(2-pyridin-2-yl-ethyl)-pyridin-2-yl]-di-p-tolyl-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

6-(2-pyridin-2-yl-ethyl)-pyridine-2-carboxylic acid methyl ester (862380-24-3) + para-methylphenylmagnesium bromide (4294-57-9) → [6-(2-pyridin-2-yl-ethyl)-pyridin-2-yl]-di-p-tolyl-methanol (539836-41-4)

Guidance literature:

In tetrahydrofuran; at 0 ℃;

DOI:10.1016/j.tet.2005.04.060

Reference yield: 72.0%

[6-(2-pyridin-2-yl-vinyl)-pyridin-2-yl]-di-p-tolyl-methanol (539836-38-9) → [6-(2-pyridin-2-yl-ethyl)-pyridin-2-yl]-di-p-tolyl-methanol (539836-41-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol;

DOI:10.1016/S0040-4039(03)00141-2

Reference yield:

2,6-bis(methoxycarbonyl)pyridine (5453-67-8) → [6-(2-pyridin-2-yl-ethyl)-pyridin-2-yl]-di-p-tolyl-methanol (539836-41-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 45 percent / tetrahydrofuran / 3 h / -78 - 20 °C

2: 83 percent / BuLi / tetrahydrofuran / 1.5 h / -40 °C

3: 60 percent / Pd/C; hydrogen / ethanol; tetrahydrofuran / 24 h

4: 76 percent / NaHDMS; PhNTf₂ / tetrahydrofuran

5: 72 percent / hydrogen; Pd/C / ethanol; tetrahydrofuran / 1.5 h

With palladium on activated charcoal; n-butyllithium; N,N-phenylbistrifluoromethane-sulfonimide; hydrogen; sodium hexamethyldisilazane; In tetrahydrofuran; ethanol;

DOI:10.1016/j.tet.2005.04.060

upstream raw materials:

[6-(2-pyridin-2-yl-vinyl)-pyridin-2-yl]-di-p-tolyl-methanol

6-(2-pyridin-2-yl-ethyl)-pyridine-2-carboxylic acid methyl ester

para-methylphenylmagnesium bromide

6-pyridin-2-yl-ethynyl-pyridine-2-carboxylic acid methyl ester

Downstream raw materials:

methyl 6-O-[6-(2-pyridin-2-yl-ethyl)-pyridin-2-yl]-di-p-tolyl-methyl-α-D-glucopyranoside