C₃₂H₂₂ClF₆NO₄

Base Information

• Chemical Name: C₃₂H₂₂ClF₆NO₄
• CAS No.: 1372925-60-4
• Molecular Formula: C₃₂H₂₂ClF₆NO₄
• Molecular Weight: 633.974
• Mol file: 1372925-60-4.mol

Synonyms:C₃₂H₂₂ClF₆NO₄

Chemical Property of C₃₂H₂₂ClF₆NO₄

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of C₃₂H₂₂ClF₆NO₄

There total 3 articles about C₃₂H₂₂ClF₆NO₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

C25H17F6NO3 (1372925-38-6) + 4-chlorobenzaldehyde (104-88-1) → C32H22ClF6NO4 (1372925-60-4)

Guidance literature:

With C₅₀H₆₃NOSi₂; In toluene; at 20 ℃; for 0.5h; optical yield given as %ee; stereoselective reaction; Molecular sieve; Inert atmosphere;

DOI:10.1021/ja3022939

Reference yield:

3,5-bis(trifluoromethyl)benzyl chloroformate (1372925-86-4) → C32H22ClF6NO4 (1372925-60-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 0.5 h / -60 °C

1.2: -60 - 20 °C

2.1: C₅₀H₆₃NOSi₂ / toluene / 0.5 h / 20 °C / Molecular sieve; Inert atmosphere

With C₅₀H₆₃NOSi₂; potassium tert-butylate; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; 2.1: Aldol addition;

DOI:10.1021/ja3022939

Reference yield:

1-Phenyl-3-methylindolin-2-one (23210-22-2) → C32H22ClF6NO4 (1372925-60-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 0.5 h / -60 °C

1.2: -60 - 20 °C

2.1: C₅₀H₆₃NOSi₂ / toluene / 0.5 h / 20 °C / Molecular sieve; Inert atmosphere

With C₅₀H₆₃NOSi₂; potassium tert-butylate; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; 2.1: Aldol addition;

DOI:10.1021/ja3022939

upstream raw materials:

3,5-bis(trifluoromethyl)benzyl chloroformate

C₂₅H₁₇F₆NO₃

4-chlorobenzaldehyde

1-Phenyl-3-methylindolin-2-one

Downstream raw materials:

C₃₂H₂₄ClF₆NO₃

C₂₂H₂₀ClNO

C₂₉H₂₃BrClNO₂