(R)-methyl 3-(5-((tert-butoxy carbonyl)amino)-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorobenzoate

Base Information

Chemical Name:(R)-methyl 3-(5-((tert-butoxy carbonyl)amino)-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorobenzoate
CAS No.:1600512-50-2
Molecular Formula:C₂₀H₂₇FN₂O₆S
Molecular Weight:442.509
Hs Code.:

Synonyms:(R)-methyl 3-(5-((tert-butoxy carbonyl)amino)-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorobenzoate

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Chemical Property of (R)-methyl 3-(5-((tert-butoxy carbonyl)amino)-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorobenzoate

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Technology Process of (R)-methyl 3-(5-((tert-butoxy carbonyl)amino)-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorobenzoate

There total 4 articles about (R)-methyl 3-(5-((tert-butoxy carbonyl)amino)-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: (R)-methyl 3-(5-amino-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorobenzoate

: 1600512-50-2
(R)-methyl 3-(5-((tert-butoxy carbonyl)amino)-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorobenzoate

Guidance literature:: With sodium hydrogencarbonate; In 1,4-dioxane;

Reference yield:

: 1600511-35-0
tert-butyl ((2R)-2-(5-bromo-2-fluorophenyl)-1-((1-cyanoethyl)thio)propan-2-yl)carbamate

: 1600512-50-2
(R)-methyl 3-(5-((tert-butoxy carbonyl)amino)-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorobenzoate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / methanol; dihydrogen peroxide; N,N-dimethyl-formamide; ethyl acetate

2: hydrogenchloride / 1,4-dioxane

3: triethanolamine / methanol; ethyl acetate

4: sodium hydrogencarbonate / 1,4-dioxane

With hydrogenchloride; triethanolamine; sodium hydrogencarbonate; potassium carbonate; In 1,4-dioxane; methanol; dihydrogen peroxide; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: (R)-tert-butyl (2-(5-bromo-2-fluorophenyl)-1-((2-cyanopropan-2-yl)sulfonyl)propan-2-yl)carbamate

: 1600512-50-2
(R)-methyl 3-(5-((tert-butoxy carbonyl)amino)-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorobenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane

2: triethanolamine / methanol; ethyl acetate

3: sodium hydrogencarbonate / 1,4-dioxane

With hydrogenchloride; triethanolamine; sodium hydrogencarbonate; In 1,4-dioxane; methanol; ethyl acetate;